Abstract: Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives. This invention also relates to precursors of such compounds, as well as the products formed from the adducts after administration.
Type:
Grant
Filed:
March 21, 2011
Date of Patent:
December 18, 2012
Assignee:
The Trustees of California State University
Abstract: Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives. This invention also relates to precursors of such compounds, as well as the products formed from the adducts after administration.
Type:
Grant
Filed:
March 12, 2007
Date of Patent:
March 22, 2011
Assignee:
The Trustees of California State University
Abstract: The present invention relates to a grass trimmer comprising a wheeled carriage, a motorized cutting element situated in a housing unit fitted to said carriage, and an integrated hand lever, the improvements comprising the cutting element being situated between front and rear wheels so as to render it unobstructed on each side, and the integrated hand lever being connected to the front wheel via a telescopic shaft so as to maintain the cutting element relatively parallel to the underside of the carriage as it is raised and lowered via adjustment to the telescopic shaft.
Abstract: The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
Type:
Grant
Filed:
June 1, 2004
Date of Patent:
March 11, 2008
Assignees:
President and Fellow of Harvard College, Children's Medical Center Corporation, NuChem Pharmaceuticals Inc.
Inventors:
Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Jr., Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft