Patents Represented by Attorney, Agent or Law Firm Mathews, Collins, Shepher & McKay, P.A.
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Patent number: 6576437
    Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: June 10, 2003
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray