Patents Represented by Attorney Matthew P. Lahive & Cockfield Vincent
  • Patent number: 5486599
    Abstract: A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly, where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: January 23, 1996
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Children's Medical Center Corporation
    Inventors: Scott Saunders, Merton Bernfield, Masato Kato