Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
Type:
Grant
Filed:
March 19, 1998
Date of Patent:
March 27, 2001
Assignee:
Sepracor, Inc.
Inventors:
Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi
Abstract: A composition of a hedgehog protein which includes as an additive cyclodextrin, a non-ionic detergent, an anionic saccharide and/or ionic salt containing zinc ions, magnesium ions, calcium ions and/or sulfate ions is especially stable at room temperature.
Abstract: The present invention makes available an interaction trap system (hereinafter “ITS”) which is derived using recombinantly engineered prokaryotic cells.
Type:
Grant
Filed:
April 21, 1999
Date of Patent:
March 13, 2001
Assignee:
President and Fellows of Harvard College
Inventors:
Simon Dove, Keith J. Joung, Ann Hochschild
Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of novel a transcriptional regulatory factor, referred to hereinafter as “Insulin Promoter Factor 1” or “Ipf1”.
Abstract: The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis of 3-hydroxy- and 3-amino-4(1H)-quinazolinones via the reaction of an appropriate 2-aminobenzamide compound with a carboxylic acid or acyl halide at ambient temperature performed on a solid support or in solution.
Abstract: Novel synthetic transcriptional modulators having at least one selected ligand linked to at least one transcriptional modulating portion are described. The transcriptional modulators of the present invention can include a ligand linked to a chemical moiety. These transcriptional modulators can be used to selectively control gene expression and to identify components of the transcriptional machinery.
Type:
Grant
Filed:
December 9, 1998
Date of Patent:
February 6, 2001
Assignee:
President and Fellows of Harvard College
Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
Type:
Grant
Filed:
June 25, 1999
Date of Patent:
January 30, 2001
Assignee:
Sepracor, Inc.
Inventors:
Gregory D. Cuny, James R. Hauske, Michael Z. Hoemann, Richard F. Rossi, Roger L. Xie
Abstract: Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.
Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
Type:
Grant
Filed:
March 14, 1997
Date of Patent:
January 23, 2001
Assignee:
Sepracor, Inc.
Inventors:
Gregory D. Cuny, Jingrong Cao, James R. Hauske
Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
Type:
Grant
Filed:
June 18, 1998
Date of Patent:
January 9, 2001
Assignee:
Sepracor, Inc.
Inventors:
Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi
Abstract: Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. The patched genes permit production of patched protein and production of antibodies that bind to patched proteins. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
Type:
Grant
Filed:
October 20, 1997
Date of Patent:
January 9, 2001
Assignee:
The Board of Trustees of the Leland S. Stanford
University
Inventors:
Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson
Abstract: The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides.
Type:
Grant
Filed:
March 27, 1998
Date of Patent:
January 9, 2001
Assignee:
The Board of Trustees of the Leland Stanford Junior
University
Inventors:
Gerald R. Crabtree, Jeffrey P. Northrop, Steffan N. Ho
Abstract: A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. The aromatic compound comprises an activated substituent, X, said activated substituent being a moiety such that its conjugate acid HX has a pKa of less than 5.0. The catalyst is preferably a soluble palladium complex in the presence of supporting ligands.
Type:
Grant
Filed:
December 8, 1998
Date of Patent:
December 26, 2000
Assignee:
Massachusetts Institute of Technology
Inventors:
Stephen L. Buchwald, John P. Wolfe, Michael Palucki
Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
Type:
Grant
Filed:
December 20, 1994
Date of Patent:
November 21, 2000
Assignee:
Ariad Pharmaceuticals, Inc.
Inventors:
Vivian Berlin, Maria Isabel Chiu, Guillaume Cottarel, Veronique Damagnez
Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .xi.
Type:
Grant
Filed:
September 16, 1998
Date of Patent:
October 31, 2000
Assignees:
Board of Trustees of Leland Stanford Jr. University, President and Fellows of Harvard College
Inventors:
Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Steffan N. Ho, Peter Belshaw
Abstract: The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of chiral or prochiral substrates that contain reactive .pi.-systems, in the present of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product.
Type:
Grant
Filed:
January 13, 1998
Date of Patent:
October 10, 2000
Assignee:
President and Fellows of Harvard College
Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
Type:
Grant
Filed:
January 23, 1998
Date of Patent:
October 3, 2000
Assignee:
ARIAD Pharmaceuticals, Inc.
Inventors:
Vivian Berlin, Maria Isabel Chiu, Guillaume Cottarel, Veronique Damagnez
Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacteria microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
Type:
Grant
Filed:
December 11, 1998
Date of Patent:
August 15, 2000
Assignee:
Sepracor, Inc.
Inventors:
Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi, Roger L. Xie
Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.
Type:
Grant
Filed:
September 16, 1998
Date of Patent:
May 16, 2000
Assignees:
Board of Trustees of Leland S, Stanford, Jr. University, President and Fellows of Harvard College
Inventors:
Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Steffan N. Ho, Peter Belshaw