Abstract: The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis.
Type:
Grant
Filed:
April 11, 1996
Date of Patent:
September 12, 2000
Assignees:
Mitotix, Inc., The John Hopkins University
Inventors:
Vivian Berlin, David E. Levin, Yoshikazu Ohya