Patents Represented by Attorney, Agent or Law Firm Matthew W. Knight
  • Stem cell factor formulations and methods
    Patent number: 6288030
    Abstract: The present invention relates to lyophilized formulations of Stem Cell Factor (SCF) with increased stability. The formulations of lyophilized SCF include amino acid buffers and sucrose. Methods of producing said formulations are also disclosed in the specification.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: September 11, 2001
    Assignee: Amgen Inc.
    Inventor: Susan I. Hershenson
  • G-CSF hybrid molecules and pharmaceutical compositions
    Patent number: 6261550
    Abstract: The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) analogs and compositions containing such analogs which retain the three-dimensional structure of the internal core of the four alpha helical bundle of G-CSF. In another aspect, such G-CSF analogs can also be attached with biologically active proteins to form hybrid molecules and still retain G-CSF structural integrity. Also provided are methods for determining and preparing analog or hybrid molecules and modifications.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: July 17, 2001
    Assignee: Amgen Inc.
    Inventor: Timothy David Osslund
  • Stem cell factor formulations and methods
    Patent number: 6020469
    Abstract: Disclosed is a method of preparing a lyophilized stem cell factor (SCF). The method comprises mixing the SCF with histidine and/or glutamic acid and lyophilizing the formulation. Optionally, a bulking agent or an osmolarity regulating agent is included in the formulation prior to lyophilization.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: February 1, 2000
    Assignee: Amgen Inc.
    Inventor: Susan I. Hershenson
  • Stem cell factor formulations and methods
    Patent number: 5965522
    Abstract: The invention relates to a novel formulation of stem cell factor. The formulation contains histidine, glutamic acid, sucrose and mannitol. The formulation has a pH between 5.0 and 6.0 and has been lyophilized.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: October 12, 1999
    Assignee: Amgen Inc.
    Inventor: Susan I. Hershenson
  • Stem cell factor analog compositions and method
    Patent number: 5885962
    Abstract: The present invention relates to stem cell factor analog polypeptide compositions, and vectors, host cells, and processes for recombinant DNA production of the present stem cell factor analogs. Pharmaceutical compositions and methods of use are also disclosed.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: March 23, 1999
    Assignee: Amgen Inc.
    Inventor: Hsieng Lu