Abstract: Novel thyroid receptor ligands are provided having the general formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolic dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
Type:
Grant
Filed:
January 23, 2004
Date of Patent:
March 11, 2008
Assignees:
Bristol-Myers Squibb Company, Karo Bio AB
Inventors:
William N. Washburn, Wei Meng, Denis E. Ryono, Bruce A. Ellsworth, Thomas Ericsson, Mahmoud Rahimi-Ghadim, Neeraj Garg, Johan Malm
Abstract: This invention provides a dosage form and a method of administering an anti-tumor composition comprising tegafur, uracil and folinic acid to potentiate the coadministration of oxaliplatin.