Abstract: aP2 inhibiting compounds are provided having the formula
wherein A, B, X, and Y are as described herein.
A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.
Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivityassociated with psychopathological disturbance andstress.
Type:
Grant
Filed:
July 23, 1997
Date of Patent:
September 26, 2000
Assignee:
Dupont Pharmaceuticals Co.
Inventors:
Liqi He, Paul Joseph Gilligan, Argyrios Georgios Arvanitis, Robert John Chorvat