Patents Represented by Attorney Max Bachrach

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  • Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
    Patent number: 8293878
    Abstract: Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: October 23, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Nicole Cathleen Goodwin, Bryce Alden Harrison, Shinya Iimura, Ross Mabon, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang, Matthew Mangzhu Zhao
  • Solid forms of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol and methods of their use
    Patent number: 8217156
    Abstract: Solid forms of anhydrous (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol are disclosed, in addition to methods of their use in the treatment of various diseases and disorders.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: July 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Susan Margaret De Paul, Anett Perlberg, Matthew Mangzhu Zhao
  • LIMK2 inhibitors, compositions comprising them, and methods of their use
    Patent number: 8193202
    Abstract: Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 5, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Nicole Cathleen Goodwin, Bryce Alden Harrison, Jason Patrick Healy, Ying Liu, Ross Mabon, Brett Marinelli, David Brent Rawlins, Dennis Stewart Rice, Norris Andrew Whitlock
  • Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1- (4-chloro-2-(3-methyl-1H-pyrazol-1-YL)phenyl)2,2,2-trifluoroethoxy)-pyrimidin-4-YL)phenyl)propanoate and methods of their use
    Patent number: 8193204
    Abstract: Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: June 5, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Susan De Paul, Ramanaiah C. Kanamarlapudi, Anett Perlberg, Haiming Zhang
  • Aryl pyridines and methods of their use
    Patent number: 8153804
    Abstract: Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: April 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, James E. Tarver, Jr., Qinghong Fu, Michael Victor Voronkov, Doan Hackley, Michael E. Mertzman, Marianne Carlsen
  • Methods of using and compositions comprising tryptophan hydroxylase inhibitors
    Patent number: 8093291
    Abstract: Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Philip Manton Brown, Qingyun Liu
  • Methods of preparing imidazole-based compounds
    Patent number: 8093280
    Abstract: Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Wenxue Wu, Jie Yan, Haiming Zhang
  • 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use
    Patent number: 8093245
    Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Alexander Heim-Riether, Theodore C. Jessop, James E. Tarver, Jerry A. Taylor
  • O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
    Patent number: 8093246
    Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Jason P. Healy, Alexander Heim-Riether, Theodore C. Jessop, Philip E. Keyes, Min Shen, James E. Tarver, Jerry A. Taylor, Xiaolian Xu
  • Multicyclic amino acid derivatives and methods of their use
    Patent number: 8063057
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 22, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Brett Marinelli, Lakshama Samala, Zhi Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
    Patent number: 8026347
    Abstract: Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: September 27, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Nicole Cathleen Goodwin, Bryce Alden Harrison, Shinya Iimura, Ross Mabon, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang, Matthew Mangzhu Zhao
  • Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use
    Patent number: 7998994
    Abstract: Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: August 16, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Suzanne Marie Buttar, Christopher Stephen Frampton
  • 1-phenyl-1H-pyrazole-based compounds
    Patent number: 7968729
    Abstract: Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Hugh Alfred Burgoon, Jr., Shinya Iimura, Ramanaiah C. Kanamarlapudi, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang
  • Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
    Patent number: 7968559
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Methods of preparing imidazole-based bicyclic compounds
    Patent number: 7968726
    Abstract: Methods of preparing compounds of formula I are disclosed:
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Jason Guohua Chen, Weifeng Hu, Renmao Liu, Yuelie Lu, Wenxue Wu, Xiaogen Yang
  • Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols
    Patent number: 7951941
    Abstract: Methods of preparing 5-alkyl-7H-pyrrolo[2,3-d]pyrimidin-4-ols are described, as are novel compounds useful in their preparation.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: May 31, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • Synthesis of piperazines, piperidines and related compounds
    Patent number: 7919618
    Abstract: Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 5, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Jr., Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • Process for the preparation of substituted phenylalanines
    Patent number: 7897763
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 1, 2011
  • Methods and compositions for treating pulmonary hypertension and related diseases and disorders
    Patent number: 7875622
    Abstract: Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also disclosed.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: January 25, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventor: Arthur T. Sands
  • Process for the preparation of substituted phenylalanines
    Patent number: 7855291
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 21, 2010