Patents Represented by Attorney Maynard R. Johnson

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  • Halophenyl acetamidines as anxiolytic antidepressants
    Patent number: 3983250
    Abstract: A method useful for alleviating central nervous system depression and anxiety symptoms comprises administration to animals of an effective amount of an N,N'-dialkyl-2-halophenyl acetamidine. Compositions useful in practicing the method are also disclosed.
    Type: Grant
    Filed: October 9, 1975
    Date of Patent: September 28, 1976
    Assignee: The Dow Chemical Company
    Inventors: Abdulmuniem H. Abdallah, Philip J. Shea
  • N,N'-Disubstituted benzamidines
    Patent number: 3972931
    Abstract: N,N'-Disubstituted benzamidine compounds such as N,N'-dimethyl-3,4-dichlorobenzamidine, and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylacetonitrile with an alkylamine and alkylammonium salt or alternatively, by reaction of the acetonitrile or corresponding N-alkylphenylacetamide with a trialkyloxonium fluoroborate followed by reaction with a primary alkylamine. The compounds have pharmacological activity as antidepressants and antianxiety or calming agents.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: August 3, 1976
    Assignee: The Dow Chemical Company
    Inventor: James R. McCarthy, Jr.
  • Disintegrating agent for tablets
    Patent number: 3951821
    Abstract: Disintegration of tablets is improved by the incorporation therein of a plurality of small tubules. The tubules can be prepared by subdivision of hollow fibers such as cellulose or cellulose acetate hollow fibers having inside diameters on the order of 50-300 microns into segments 100-1000 microns in length. Tablets and methods for their preparation are disclosed.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: April 20, 1976
    Assignee: The Dow Chemical Company
    Inventor: William G. Davidson
  • Anti-inflammatory methods utilizing certain thioureas
    Patent number: 3950538
    Abstract: A method of alleviating symptoms of inflammation in a mammal suffering from an inflammatory condition which comprises the administration to such mammal of a pharmaceutically effective amount of a 1-aryl-3-(2-hydroxyethyl)thiourea derivative.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: April 13, 1976
    Assignee: The Dow Chemical Company
    Inventor: Philip J. Shea
  • Determination of calcium
    Patent number: 3938954
    Abstract: An improved reagent system for determining calcium by the orthocresolphthalein complexone color reaction. The reagent utilizes an alkaline buffer containing an aminoloweralkanol providing a pH of about 10.2 - 10.5. A method for using the reagent is also described. The composition is stable for extended periods.
    Type: Grant
    Filed: January 20, 1975
    Date of Patent: February 17, 1976
    Assignee: The Dow Chemical Company
    Inventors: William S. Stavropoulos, Bernard J. Thiegs, Robert F. Mack
  • Phenyl -thiourea, -carbothioamide and -carbonothioamide derivatives
    Patent number: 3933833
    Abstract: Disclosed are various phenyl -thiourea, -carbothioamide and -carbonothioamide derivatives which are useful in alleviating symptoms and conditions of inflammation.
    Type: Grant
    Filed: May 30, 1974
    Date of Patent: January 20, 1976
    Assignee: The Dow Chemical Company
    Inventors: Donald L. Trepanier, Thomas C. Britton
  • Substituted phenylthioamidines
    Patent number: 3933912
    Abstract: Substituted phenylthioamidine compounds such as 2-(4-chlorophenylthio)acetamidine; 2-(4-chlorophenylthio)-acetamidoxime; and their pharmaceutically acceptable salts are prepared by the reaction of a substituted phenylthioacetonitrile with hydroxylamine hydrochloride or with methanol followed by ammonium chloride. The compounds have antimicrobial activity and also inhibit ADP-induced aggregation of blood platelets.
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: January 20, 1976
    Assignee: The Dow Chemical Company
    Inventor: Earl R. Bockstahler
  • Halophenyl acetamidines as anxiolytic antidepressants
    Patent number: 3934020
    Abstract: A method useful for alleviating central nervous system depression and anxiety symptoms comprises administration to animals of an effective amount of an N,N'-dialkyl-2-halophenyl acetamidine. Compositions useful in practicing the method are also disclosed.
    Type: Grant
    Filed: October 2, 1974
    Date of Patent: January 20, 1976
    Assignee: The Dow Chemical Company
    Inventors: Abdulmuniem H. Abdallah, Philip J. Shea
  • Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythemic agents
    Patent number: 3932664
    Abstract: Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl[dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-.beta.-dimethylamino-p-phenetidine with a substituted organic compound such as allyl bromide. The quaternary ammonium compounds are useful in alleviating or inhibiting cardiac arrhythmias when the quaternary ammonium compounds, or compositions comprising the same are administered to animals.
    Type: Grant
    Filed: July 1, 1974
    Date of Patent: January 13, 1976
    Assignee: The Dow Chemical Company
    Inventor: Stanley J. Strycker