Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

Abstract: A hearing-aid device comprising a housing and circuitry module, wherein the circuitry module comprises a battery, a microphone, and a receiver, and the circuit module is inserted in the hearing aid housing. The hearing aid device further comprises a retractable battery sleeve, wherein a battery slot is exposed when the battery sleeve is retracted, and a battery can be inserted into the battery slot from either side of the battery slot with either polarity. The hearing aid housing may comprise an ear-tip, wherein a microphone is mounted in the hearing aid housing near the ear-tip and the microphone receives sounds through at least one sound inlet located on a side surface of the hearing aid housing. The ear-tip additionally comprises three flanges decreasing in size toward the flange closest to the ear canal, and the hearing aid can be inserted into the ear canal in any orientation.

Abstract: Methods and systems for a light source assembly supporting direct coupling to a photonically enabled complementary metal-oxide semiconductor (CMOS) chip are disclosed. The assembly may include a laser, a microlens, a turning mirror, reciprocal and/or non-reciprocal polarization rotators, and an optical bench. The laser may generate an optical signal that may be focused utilizing the microlens. The optical signal may be reflected at an angle defined by the turning mirror, and may be transmitted out of the light source assembly to one or more grating couplers in the chip. The laser may include a feedback insensitive laser. The light source assembly may include two electro-thermal interfaces between the optical bench, the laser, and a lid affixed to the optical bench. The turning mirror may be integrated in a lid affixed to the optical bench or may be integrated in the optical bench.

Abstract: Certain embodiments of the present invention provide a system for analyzing a treatment of a patent including: an interactive image editor for allowing a user to interact with a first set image data corresponding to a pre-treatment radiological study of a patient, the first set of image data including an untreated clinical area of interest, such that the user is capable of interacting with the first set of image data to form a target outcome image for the clinical area of interest; a criterion determination module for allowing the user to determine a target outcome criterion; processing module for performing a comparison by comparing the first set of image data with a second set of image data corresponding to a post-treatment radiological study of the patient, the second set of image data including a treated clinical area of interest; and a criterion evaluation module for automatically evaluating the comparison to determine a post-treatment effect.

Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.

Abstract: A drill bit including a shaft which has a pyramidal shaped end defining a drill tip with a plurality of edges defining the pyramidal shape. One or more recesses are provided for directing away debris produced while drilling, the at least one recess having a first portion extending along the shaft and a second portion having a first portion extending along the shaft and a second portion which extends along the drill tip; wherein the. The second portion which extends along the drill tip. The second portion of the at least one recess extends along an edge of the drill tip.

Abstract: A system and method for displaying a set of data with a virtually dissected anatomical structure. In an embodiment, the anatomical structure is a colon and various attributes of the colonic lumen are assigned a color. In an embodiment, a virtual dissection of the colon is created by mapping a three-dimensional data set to a two dimensional data set. A plurality of display index values are computed which correspond to the three-dimensional data set. Various colors are assigned to specific display index values. The three-dimensional display index values are mapped to a two-dimensional set of display index values. As directed by a user, various color cues may be displayed with the virtually dissected lumen to provide color highlights to various aspects of the colon, such as highlighting shape, fluid, or fecal presence.

Abstract: A backside illuminated image sensor includes a photodiode, formed below the top surface of a semiconductor substrate, for receiving light illuminated from the backside of the semiconductor substrate to generate photoelectric charges, a reflecting gate, formed on the photodiode over the front upper surface of the semiconductor substrate, for reflecting light illuminated from the backside of the substrate and receiving a bias to control a depletion region of the photodiode, and a transfer gate for transferring photoelectric charges from the photodiode to a sensing node of a pixel.

Abstract: A transceiver comprising a CMOS chip and a laser coupled to the chip may be operable to communicate an optical source signal from a semiconductor laser into the CMOS chip. The optical source signal may be used to generate first optical signals that are transmitted from the CMOS chip to optical fibers coupled to the CMOS chip. Second optical signals may be received from the optical fibers and converted to electrical signals via photodetectors in the CMOS chip. The optical source signal may be communicated from the semiconductor laser into the CMOS chip via optical fibers in to a top surface and the first optical signals may be communicated out of a top surface of the CMOS chip. The optical source signal may be communicated into the CMOS chip and the first optical signals may be communicated from the CMOS chip via optical couplers, which may comprise grating couplers.

Abstract: For providing to a user on a communication terminal (1) media content (31) from a content server (3), a Session Initiation Protocol message, addressed to a resource identifier identifying the media content (31), is transmitted from the communications terminal (1) to a Call Session Control Function unit (S-CSCF), in response to the user activating a hyperlink associated with the media content (31). If there are filter criteria (iFC) associated with the user and associating the first message with an application server (SIP-AS), the resource identifier is transmitted from the Call Session Control Function unit (S-CSCF) to the application server (SIP-AS). The application server (SIP-AS) transmits to the communication terminal (1) accessing means for the user to retrieve the media content (31) from the content server (3).

Abstract: Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided.

Abstract: Certain embodiments of the present invention provide a system and method for temporally aligning a plurality of cardiac image sequences. The method includes performing a locally linear embedding algorithm on a first set of cardiac image sequences and on a second set of cardiac image sequences. A graphical representation is created for the first set of cardiac image sequences and the second set of cardiac image sequences. A determination is made whether the first set of cardiac image sequences and the second set of cardiac image sequences were generated from a similar point of view. If a similar point of view is found, the first graphical representation and the second graphical representation are aligned using a minimization function. If a similar point of view is not found, the graphs are aligned with a template and then aligned with each other using the minimization function.

Abstract: Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.

Abstract: Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.

Abstract: The invention relates to a method and a system for creating an optimized communications link (SC/DC) between at least two mobile network nodes (10, 11), whereby corresponding interface management modules (40, 41) create lookup tables (401, 411) of available network interfaces (30, 31), whereby configuration data are transmitted between the mobile network nodes via an available signaling channel (sSC), whereby at least one signaling channel (SC) is created via one of the available network interfaces (30, 31) based on the configuration data by means of corresponding signaling router modules in order to transmit configuration data, and whereby at least one data channel (DC) is created via one of the available network interfaces (30, 31) based on the configuration data by means of corresponding data router modules 60, 61.

Abstract: A charge transfer transistor includes: a first diffusion region and a second diffusion region; a gate for controlling a charge transfer from the first diffusion region to the second diffusion region by a control signal; and a potential well incorporated under the gate, wherein the first diffusion region is a pinned photodiode. A pixel of an image sensor includes: a photodiode for generating and collecting a photo generated charge; a floating diffusion region for serving as a photo generated charge sensing node; a transfer gate for controlling a charge transfer from the photodiode to the floating diffusion region by a control signal; and a potential well incorporated under the transfer gate.

Abstract: The present invention provides devices, kits and methods for illustrating travel time. The device includes a display board, a starting point indicator, a destination indicator, a travel path, and a progress indicator. The starting point indicator represents a starting point and is adapted for display on the display board. The destination indicator represents a destination point and is adapted for display on the display board. The travel path represents a path of travel between the starting point and the destination point. The progress indicator is adapted to indicate a point between the starting point indicator and the destination indicator and is adapted for movement along the travel path. A kit for illustrating travel time comprises a display board, a location indicator set, and a progress indicator. A method for illustrating travel time comprises displaying a starting point indicator on a display board, displaying a destination indicator on the display board, and displaying a progress indicator.

Abstract: An electrically powered flame simulator comprises at least two light sources, an integrated circuit electrically connected to the light sources for intermittently illuminating at least one of the light sources independently of other light sources such that the light sources together provide the effect of a flickering movement, and a power source for providing power to the integrated circuit. The flame simulator may be mounted in a decorative or ornamental device such as a candle or fire log, or used on decorative clothing, or may be part of a hazard or warning system. One or more solid state light sources may also be used.

Abstract: Certain embodiments of the present technology provide improved amplification circuits and hearing aids that can utilize such amplification circuits. In an embodiment, for example, an amplification circuit includes: a first sub circuit configured to create a voltage drop when a supply voltage is above a first voltage; and a second sub circuit configured to create a reverse voltage drop when the supply voltage is below a second voltage, wherein the first and second sub circuits operate to maintain idling current within a range. Certain embodiments of the present technology also provide hearing aids that include removable dampers.