Abstract: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds.

Abstract: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using rapid DNA extraction followed by nucleic acid amplification with or without enrichment for mutant DNA. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of benign, premalignant, or malignant neoplasms in humans or other animals that contain a mutation that is associated with the neoplasm through detection of the mutated nucleic acid of the neoplasm in plasma or serum fractions.

Abstract: This invention provides reagents and methods for specifically delivering antibiotic, antimicrobial and antiviral compounds, drugs and agents to phagocytic mammalian cells. The invention also relates to specific delivery to and uptake of such compounds by phagocytic cells. The invention specifically relates to reagents and methods for facilitating the entry of antibiotic, antimicrobial and antiviral compounds, drugs and agents into phagocytic cells. The invention specifically provides compositions of matter and pharmaceutical embodiments of such compositions comprising such antibiotic, antimicrobial or antiviral compounds, drugs and agents conjugated to, impregnated with or coated onto particulate carriers generally termed microparticles. In particular embodiments, the antibiotic, antimicrobial and antiviral compounds, drugs and agents are covalently linked to a microparticle via a specifically-degradable linker molecule which is the target of a microorganism-specific protein having enzymatic activity.

Abstract: A toll saving method and apparatus for a remote access system is provided. A first communication device receives a connection request from a second communication device. The first communication device then decodes caller identification information from the connection request to determine a user identity, without completing the connection request. The first communication device determines whether an event associated with the user identity has occurred. If the event associated with the user identity has not occurred, the connection request is not completed. In a preferred embodiment, the toll saving method and apparatus allows an email user to call an ISP to determine whether unaccessed email is present in the user's account. If no email is present in the user's account, the call is never answered and no toll charges are incurred.

Abstract: A data processing system comprises a magnetic or optical disc 1, a disc controller 2, and a main data processing unit 5 communicating with the controller by means on an interface 6. The controller 2 comprises an internal processing unit which receives requests from the main data processing unit 5 for data to be read from the disc 1, and controls retrieval of the data from the disc 1 and transmission of data to the main data processing unit 5 via the interface 6. The controller 2 further comprises a buffer 3 for data read from the disc 1 prior to transmission to the main data processing unit 5. The controller 2 also comprises a look-up table 4 for modifying the data read from the disc 1 in accordance with predetermined. modification criteria prior to transmission to the main data processing unit 5. The system may be used in colour processing of image data, with the disc controller providing primary colour correction.

Abstract: A furniture glide assembly including a threaded rod, a convex glide foot, and an retractable glide foot, wherein the furniture associated with the glide assembly is essentially immobile when the glide foot is engaged, and wherein the furniture can be easily moved when the glide foot is retracted.