Patents Represented by Attorney, Agent or Law Firm McDonnel Boehnen Hulbert & Berghoff
  • Patent number: 6221914
    Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: April 24, 2001
    Assignee: Array Biopharma Inc.
    Inventors: Laurence E. Burgess, James P. Rizzi
  • Patent number: 6137188
    Abstract: Disclosed is a system and method for supplying power to multiple devices using a single voltage regulator. The present invention includes a comparator that compares the voltage identification codes from multiple devices in a system. If all the devices have the same value for the voltage identification code, then the comparator forwards the code to a voltage identification input of a programmable voltage regulator, which then outputs a power supply voltage at a level corresponding to the voltage identification code value of the devices. If any device present in the system has a different value for its voltage identification code, then the comparator outputs a predetermined value to the programmable voltage regulator that prevents the voltage regulator from outputting a power supply voltage.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: October 24, 2000
    Assignee: 3Com Corporation
    Inventors: Craig G. Mitchell, Christian A. D'Souza, Michael P. Dempsey, Chandra S. Pandey
  • Patent number: 6110480
    Abstract: The present invention teaches method for culturing nematode pesticidal compositions, to produce at a high yield, and generate biotic compositions that are effective as insecticides with high pesticidal activity and preventive effects.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: August 29, 2000
    Assignee: Development Center for Biotechnology
    Inventors: Linag-Kuang Chu, Chiao Po Lin, Chien-Ming Shih, Tsae Yueh Lee, Tai-Sen Soong
  • Patent number: 6084098
    Abstract: Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH;R.sub.1, R.sub.2 and R.sub.3 independently represent organic or inorganic substituents;R.sub.4 and R.sub.4 ' independently represent hydrogen, alkyl or form a ring with the atom to which they are attached;R.sub.5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R.sub.6 represents hydrogen or alkyl; or R.sub.5 and R.sub.6 form a ring together with the atoms to which they are attached; andR.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 independently represent hydrogen or alkyl,which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: July 4, 2000
    Assignee: Neurogen Corporation
    Inventors: Renata Xavier Kover, Silva Terdjanian, Jennifer Tran, Andrew Thurkauf
  • Patent number: 5973120
    Abstract: An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: October 26, 1999
    Assignees: Yale University, University of Kansas Medical Center
    Inventors: Stephen T. Reeders, Karen E. Morrison, Billy G. Hudson
  • Patent number: 5824745
    Abstract: Post consumer recyclable plastics are combined with a ethylene-octene copolymer and a polyamide to prepare a resin composition that can be used in conventional molding processes to fabricate new and useful plastic articles of manufacture.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: October 20, 1998
    Inventor: William F. Brown
  • Patent number: 5637614
    Abstract: 6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: June 10, 1997
    Assignee: Sigma Tau
    Inventors: Piero Foresta, Mauro Marzi, Maria O. Tinti