Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.
Abstract: Disclosed is a system and method for supplying power to multiple devices using a single voltage regulator. The present invention includes a comparator that compares the voltage identification codes from multiple devices in a system. If all the devices have the same value for the voltage identification code, then the comparator forwards the code to a voltage identification input of a programmable voltage regulator, which then outputs a power supply voltage at a level corresponding to the voltage identification code value of the devices. If any device present in the system has a different value for its voltage identification code, then the comparator outputs a predetermined value to the programmable voltage regulator that prevents the voltage regulator from outputting a power supply voltage.
Type:
Grant
Filed:
May 28, 1999
Date of Patent:
October 24, 2000
Assignee:
3Com Corporation
Inventors:
Craig G. Mitchell, Christian A. D'Souza, Michael P. Dempsey, Chandra S. Pandey
Abstract: The present invention teaches method for culturing nematode pesticidal compositions, to produce at a high yield, and generate biotic compositions that are effective as insecticides with high pesticidal activity and preventive effects.
Abstract: Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH;R.sub.1, R.sub.2 and R.sub.3 independently represent organic or inorganic substituents;R.sub.4 and R.sub.4 ' independently represent hydrogen, alkyl or form a ring with the atom to which they are attached;R.sub.5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R.sub.6 represents hydrogen or alkyl; or R.sub.5 and R.sub.6 form a ring together with the atoms to which they are attached; andR.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 independently represent hydrogen or alkyl,which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
Type:
Grant
Filed:
February 26, 1999
Date of Patent:
July 4, 2000
Assignee:
Neurogen Corporation
Inventors:
Renata Xavier Kover, Silva Terdjanian, Jennifer Tran, Andrew Thurkauf
Abstract: An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome.
Type:
Grant
Filed:
March 7, 1995
Date of Patent:
October 26, 1999
Assignees:
Yale University, University of Kansas Medical Center
Inventors:
Stephen T. Reeders, Karen E. Morrison, Billy G. Hudson
Abstract: Post consumer recyclable plastics are combined with a ethylene-octene copolymer and a polyamide to prepare a resin composition that can be used in conventional molding processes to fabricate new and useful plastic articles of manufacture.
Abstract: 6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.
Type:
Grant
Filed:
April 29, 1996
Date of Patent:
June 10, 1997
Assignee:
Sigma Tau
Inventors:
Piero Foresta, Mauro Marzi, Maria O. Tinti