Abstract: An apparatus and associated methods are provided to authenticate a patient based on a biometric identifier of the patient before a prescribed dose of medical therapeutic, such as analgesics or other medication, are dispensed to the patient. Authentication takes places by pressing a button and scanning the patient's fingerprint and recording data corresponding to the fingerprint into memory. To receive the medical therapeutic, the patient can have his or her fingerprint read and compared to the stored fingerprint. If there is a match and the programmed limitations are met (e.g., a time interval has elapsed since the last dose), then the medical therapeutic is automatically dispensed to the patient. The system may be integrated with a new patient-controlled medical therapeutic device or the system may be added to an already existing device. Other features and advantages of the example embodiments are described.

Abstract: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using DNA extraction with or without enrichment for mutant DNA. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of benign, premalignant, or malignant neoplasms in humans or other animals that contain a mutation that is associated with the neoplasm through detection of the mutated nucleic acid of the neoplasm in plasma or serum fractions.

Abstract: The present invention provides a device which facilitates communications between a computer system and a data network by buffering data in transit between the computer system and the data network in a single buffer memory which can be flexibly partitioned into separate transmit and receive buffers. This flexible partitioning allows the relative sizes of the transmit and receive buffers to be optimized across a wide range of buses, data networks and network usage patterns. The transmit and receive buffers are structured as ring buffers within respectively allocated portions of the buffer memory. The buffer memory is controlled by a simple finite state machine controller, which is free from the performance impediments and higher cost associated with a microprocessor-based controller. The present invention also provides support for retransmission of packets that encounter transmission problems such as collisions during transmissions on the data network.

Abstract: A process for deprotecting RNA alkylsilyl groups comprising, contacting the groups with a solution of anhydrous triethylamine-hydrogen fluoride (aHF-TEA) in triethylamine and N-methylpyrrolidine at between 60° C.-70° C. for 0.25-24 h.

Abstract: This invention is an apparatus and a method for applying a very thin film of fluoropolymer to a substrate, and more particularly, to a substrate surface that is a heat transfer, aerodynamic, and hydrodynamic substrates. This invention is also a substrate including an extremely thin film of fluoropolymer.