Abstract: Disclosed are compounds of the formula: ##STR1## wherein Ar, R.sup.1, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF.sub.1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y.sub.1 receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.
Type:
Grant
Filed:
April 1, 1999
Date of Patent:
November 14, 2000
Assignee:
Neurogen Corporation
Inventors:
Raymond F. Horvath, James W. Darrow, George D. Maynard
Abstract: A hockey puck having a cavity and a self leveling weight disposed therein for causing the puck to topple from its side to a face when rolling and for maintaining a face of the puck substantially parallel to the playing surface.