Abstract: High concentration of free cells of heterofermentative lactic acid bacteria (LAB) in a resting or slowly growing state are used to convert fructose into mannitol. Efficient volumetric mannitol productivities and mannitol yields from fructose are achieved in a process applying cell-recycle, continuous stirred tank reactor and/or circulation techniques with native LAB cells or with LAB cells with inactivated fructokinase gene(s). Mannitol is recovered in high yield and purity with the aid of evaporation and cooling crystallization.

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A method and apparatus for spore disruption and/or detection is provided. The method involves irradiating a sample with laser light, conveniently ultraviolet radiation, to disrupt any spores present and collecting any disrupted material for analysis. The disruption can involve breaking the spore open to release intrasporal DNA which is useful for fast screening and detection equipment. The disrupted material may be collected in a collection chamber which can be flushed with an extraction fluid to collect the disrupted material. The sample is preferably concentrated in a nanovial prior to being irradiated to give sample enrichment.

Abstract: A method for the automated analysis of digital images, particularly for the purpose of assessing mitotic activity from images of histological slides for prognostication of breast cancer. The method includes the steps of identifying the locations of objects within the image which have intensity and size characteristics consistent with mitotic epithelial cell nuclei, taking the darkest 10% of those objects, deriving contours indicating their boundary shape, and smoothing and measuring the curvature around the boundaries using a Probability Density Association Filter (PDAF). The PDAF output is used to compute a measure of any concavity of the boundary—a good indicator of mitosis. Objects are finally classified as representing mitotic nuclei or not, as a function of boundary concavity and mean intensity, by use of a Fisher classifier trained on known examples.

Abstract: An image forming apparatus including: a video memory; a load management unit that loads page data on a print image into the video memory page by page; a print engine that performs printing using the page data stored in the video memory; and a main management unit that, when printing of a page is completed as part of an electronic sort process, causes the video memory to retain the page data if there is a subsequent page to be printed using the same page data as that on the page, and deletes the page data from the video memory if there is no subsequent page to be printed using the same page data as that on the page.

Abstract: The invention relates to the type 5 and type 8 capsular polysaccharides produced by overproducing S. aureus strains, and also to the immunogenic compositions and the vaccines comprising said capsular polysaccharides.

Abstract: Calibration method for calibrating transient behavior of a TLP test system. The system comprises a TLP generator, probe needles, nominally impedance matched transmission lines and measurement equipment, connected between the transmission lines and the TLP generator, for detecting transient behavior of a device under test by simultaneously capturing voltage and current waveforms as a result of generated pulses. The calibration method comprises (a) applying the TLP test system on an open and capturing first voltage and current waveforms; (b) applying the TLP test system on a calibration element having a known finite impedance and a known transient response and capturing second voltage and current waveforms; (c) transforming the captured first and second current and voltage waveforms to the frequency domain, and (d) determining calibration data for the transient behavior of the TLP test system on the basis of the transformed first and second voltage and current waveforms.

Abstract: A device for reducing sound from an air treatment unit includes, in one embodiment, an air treatment system, including a wall mount HVAC unit with a supply air opening and a return air opening. A supply air sound reducer is provided in communication with the supply air. The supply air sound reducer includes a housing defining a supply interior provided with sound reducing material. The sound reducing material is overlaid with a layer of perforated material. A return air sound reducer is provided in communication with the return air opening. The return air sound reducer includes a housing defining an interior return volume provided with sound reducing material applied to one or more inside surfaces of the interior return volume and a layer of perforated material disposed over the sound reducing material. Mid-structure including sound reducing material is disposed in each of the supply and return air assemblies.

Abstract: A slot machine method, apparatus, and computer readable storage to allow a player to make a side wager on a slot machine game. The side wager is based on a finishing order of the reels of the slot machine, which will stop spinning in a random order instead of the typical left to right order. The player can predict (or be presented with) a predicted order, and the predicted order is compared to an actual stopping order after the reels are spun to determine if the side wager is a winner, and for how much.

Abstract: The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

Abstract: A protective system for underwater installation on the propeller inhibits marine growth from fouling the propeller. The system includes a flexible material sized and shaped so as to be capable of enclosing the propeller. A member such as a clamp or clip maintains the flexible material in a state enclosing the propeller. The system further includes a link (such as a piece of line) having one end attached to the member and/or the flexible material and a free second end. The link extends to a location proximate to the boat at or above the waterline of the boat wherein the link can be retrieved by a user. A tug on the link releases the flexible material from the propeller permitting the retrieval of the link, the member and the flexible material as a unit from the propeller without the aid of a diver.

Abstract: A hydrocarbon-containing gas is mixed with an oxygen gas in a gas mixer in the presence of coarse water droplet environment, e.g., a ‘rainy’ or ‘driving rainstorm’ environment in which the water droplets generally have a size greater than 200 microns SMD. The water droplets surround and contact entrained particles in either the oxygen gas stream or the hydrocarbon-containing gas stream. The water acts to suppress, prevent and quench ignition of the hydrocarbon gas in the mixer which would otherwise be caused by energetic collisions between such particles and structures within the gas mixer. In one configuration the gas mixer includes water pipes having coarse water droplet-producing nozzles at the peripheral end thereof concentrically located within oxygen supply pipes. Additionally, nozzles introduce coarse water droplets into a pipe carrying the hydrocarbon gas and forming a mixing chamber for the hydrocarbon and oxygen gases.

Abstract: A method is presented for obtaining characteristics of a target physical entity by providing an excitation signal to the target physical entity and simultaneously measuring the response of the target physical entity. Analog signal processing is performed on the measured response to eliminate artifacts arising from a signal path outside the target physical entity and determining the characteristics from the signal processed measured response. The excitation signal and the analog signal processing are selected such that after analog signal processing of the measured signal, the analog measured signal contains artifacts which are localized in time.

Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

Abstract: The present invention relates generally to photovoltaic devices, and more particularly to photovoltaic roofing products in which a photovoltaic element is joined to a roofing substrate. In one embodiment, the present invention provides a photovoltaic roofing element comprising a roofing substrate; one or more photovoltaic cells disposed on the roofing substrate; and a colored or patterned layer disposed on the roofing substrate and visible in the area surrounding the photovoltaic cells; and an encapsulant layer disposed over the photovoltaic cells and the patterned colored layer.

Abstract: A system and method are provided for trading multiple tradeable objects. One example method includes displaying at least one combined quantity indicator representing a combined quantity associated with at least two tradeable objects, detecting an input associated with an order for a predetermined order quantity in relation to one of the combined quantity indicators, and allocating the order quantity between the at least two tradeable objects using at least one quantity allocation rule. In one example embodiment, a plurality of quantity allocation rules can be user-configurable, and different rules can be defined and applied in relation to different order types.

Abstract: A Multi-Function peripheral (MFP), a server apparatus, and a client apparatus for generating image output data from document data and transmitting the image output data to the server apparatus are each connected to a network. In the server apparatus, an output data management unit stores the received image output data in an output data storage unit. Upon receiving user authentication information that is input with a user operation on the MFP, the server apparatus determines whether the user authentication information is valid. When the user authentication information is determined to be valid, the server apparatus transmits to the MFP one or more among the stored image output data associated with the user authentication information.

Abstract: The present invention relates to processes for preparing gaseous products, and in particular, methane via the catalytic gasification of carbonaceous feedstocks in the presence of steam and an oxygen-rich gas stream. The processes comprise using at least one catalytic methanator to convert carbon monoxide and hydrogen in the gaseous products to methane and do not recycle carbon monoxide or hydrogen to the catalytic gasifier.