Patents Represented by Attorney, Agent or Law Firm McDonnell Boehnen Hulbert & Berghoff
  • Mechanism for identifying drugs for the treatment of type II diabetes
    Patent number: 7601687
    Abstract: Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a complex network of diverging and converging pathways, with alternative proteins and isoforms at almost every step in the process. We have previously shown that insulin activates the transcription of its own gene by signaling through Insulin Receptor A type (Ex11?), PI3 kinase and p70 s6 kinase. When studying the mechanisms underlying the glucose-stimulated activation of the glucokinase gene in pancreatic beta cells, we now demonstrate that also here secreted insulin is a key-factor. In contrast to the insulin gene, transcription of the glucokinase gene is promoted by signaling via Insulin Receptor B type (Ex11+) and protein kinase B (c-Akt).
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: October 13, 2009
    Assignee: BioCrine AB
    Inventors: Per-Olof Berggren, Barbara Leibiger, Ingo Leibiger
  • GIPs, a family of polypeptides with transcription factor activity that interact with Goodpasture antigen binding protein
    Patent number: 7601349
    Abstract: The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors. The invention further provides methods for detecting the GIP90/130 polypeptides or nucleic acid sequences, methods for inhibiting interactions between GPBP and GIP90/130 polypeptides, between pol k76 and GIP90/130 polypeptides or aggregation of GIP90/130 polypeptides, and methods for treating patients with autoimmune disorders or cancer.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: October 13, 2009
    Inventors: Juan Saus, Francisco Revert-Ros
  • Method and packaging machine for packaging a product arranged in a tray
    Patent number: 7600358
    Abstract: A method for packaging a product arranged in a tray is provided. An upper film located in a distance above the product is clamped along an edge surrounding the tray and is deformed in a direction extending away from the product. Subsequently, evacuating of the space surrounding the product is performed, then a raising of the tray towards the upper film and finally a sealing of the film and of the edge of the tray. In this way, the seam of the upper film and the edge of the tray is attained to be free from creases such that a long-living and good looking package is produced. Additionally, a packaging machine for performing the method is provided.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: October 13, 2009
    Assignee: MULTIVAC Sepp Haggenmuller GmbH & Co. KG
    Inventor: Johann Natterer
  • Rounded-particle plastic powder in particular for application in laser sintering, method for production of such a powder and laser sintering process using such a powder
    Patent number: 7601422
    Abstract: In a laser sintering method for producing a three-dimensional object wherein subsequent layers of the object to be formed are subsequently solidified on positions corresponding to the object, as a build-up material, a powder is used wherein the upper grain limit of the powder particles is below 100 ?m, the D0.5-value is below 55 ?m, the BET-surface is smaller than 5 m2/g and the grains of the powder basically have a spherical shape.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: October 13, 2009
    Assignee: EOS GmbH Electro Optical Systems
    Inventors: Mandy Gersch, Frank Müller, Thomas Mattes, Peter Keller
  • Inflatable tree apparatus
    Patent number: 7601407
    Abstract: An inflatable tree that may be used as an indoor or outdoor decoration, particularly during the Christmas holiday season. In one embodiment, the inflatable tree comprises an inflatable bladder having a substantially conical or cylindrical prism shape, wherein the axial direction of the bladder is oriented along a vertical axis, and a plurality of conical skirts attached to the bladder, wherein the plurality of conical skirts are attached at different points along the vertical axis.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: October 13, 2009
    Inventor: Allen Jacob Irvine
  • Compact, integrated system for processing test samples
    Patent number: 7601300
    Abstract: An integrated instrument processes fluid test samples using disposable test devices. The test devices are carried in a carrier. The instrument includes a vacuum station receiving the carrier for batch loading of the test devices with fluid samples to be tested. The user removes the carrier from the vacuum station and inserts it into a loading station of a separate carrier and test device processing subsystem. This subsystem includes a transport system moving the carrier through the instrument where various modules perform operations on the test devices, including sealing the test devices, loading the test devices into an incubation station, incubation of the test devices, test device reading, and test device disposal.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: October 13, 2009
    Assignee: Biomérieux, Inc.
    Inventors: Ross Mitchell Blanton, Michael James Justin, James Clement Bishop, Jacky S. Yam, Robert J. Polster, Mark Joseph Fanning
  • Dual elevation weapon station and method of use
    Patent number: 7600462
    Abstract: A gimbaled weapon system (GWS) implements methods for identifying and tracking a target. In one aspect, the sighting system of the GWS moves independently in elevation from the weapon cradle and tracks a target while the weapon cradle and attached weapon are maintained in a non-hostile position, such as a stowed or vertical position. In another aspect, the method uses a system of networked sensors in communication with an observation unit for the GWS. The sighting system is elevated using a second elevation drive to acquire a target based on signals received the system of networked sensors. The network sensors provide coordinates of probable targets, which can trigger automatic tracking of the target or an alarm to notify the operator of a probable target.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: October 13, 2009
    Assignee: Recon/Optical, Inc.
    Inventor: James P. Quinn
  • Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
    Patent number: 7601818
    Abstract: This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: October 13, 2009
    Assignees: Amgen, Inc., Medarex, Inc.
    Inventors: Kenneth D. Wild, Jr., James J. S. Treanor, Haichun Huang, Heather Inoue, Tie J. Zhang, Frank Martin
  • Method and system for network management
    Patent number: 7603408
    Abstract: Methods and systems for managing a network using a handheld communications device are provided. The methods and systems provide advantages for Network Administrators that require mobility in accessing information about network connected devices and for controlling selected network management functions.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: October 13, 2009
    Assignee: 3Com Corporation
    Inventors: Brian Evan McGinnis, Vaibhavi Kothari, William Tanaka, Stephen Ngok Tsun, Les R. Stuart
  • Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
    Patent number: 7601506
    Abstract: The invention provides a simple method for diagnosing a non-symptomatic or symptomatic human or animal with transmissible spongiform encephalopathy.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: October 13, 2009
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Roy Jackman, Linda Ann Terry, Sally Jane Everest
  • Kinase inhibitors and their uses
    Patent number: 7601713
    Abstract: The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: October 13, 2009
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Pingyu Ding, Ankush Argade, Dane Goff, Rajinder Singh, Esteban Masuda, Vanessa Taylor, Sacha Holland
  • Network management system providing logic signals over communication lines for detecting peripheral devices
    Patent number: 7603486
    Abstract: A method and apparatus for detecting the presence and the type of network devices connected to a management device via transmission lines. The apparatus may include a pull-up resistor, a pull-down resistor, a filter, and a presence detector, the resistors superimposing a DC or low-frequency voltage on the transmission line. The impact, if any, of the DC voltage one communications equipment and circuitry can be reduced by a coupling that isolates the DC voltage. Similarly, the filter prevents transmitted data signals from interfering with the DC voltage level. The method and apparatus function regardless of whether the network device is functional or powered on, and different values of pull-up or pull-down resistors can be used to indicate the type of device that terminates the transmission line.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: October 13, 2009
    Assignee: 3Com Corporation
    Inventors: Linh My Le, Dwight D. Dipert, Ellen Oschmann
  • Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
    Patent number: 7601528
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: October 13, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • System and method for risk management
    Patent number: 7603303
    Abstract: A margin requirement is computed while trading. The margin requirement may be calculated while trading because the preferred system takes into account working orders to generate the margin requirement. The on the fly possibility allows the preferred system to provide pre-trade risk calculations, but can also be used to provide post-trade calculations. A generic spread number and the maximum number of outright positions are determined. Using the spread positions and the maximum number of outright positions, a spread margin and an outright margin are calculated, which when summed provide a total margin requirement. Limits based in part on the total margin requirement may be imposed on one or more traders.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: October 13, 2009
    Assignee: Trading Technologies International, Inc.
    Inventors: Henrik Kraus, Farley Owens, Jens-Uwe Schluetter
  • Circuits and methods for detecting the mode of a telecommunications signal
    Patent number: 7602805
    Abstract: A method for detecting the mode of a telecommunications signal is provided. The method receives the telecommunications signal and contemporaneously evaluates the telecommunications signal for compliance with at least two signal modes. When the evaluation indicates that the signal conforms to a first mode, the signal is processed as a first mode signal. When the evaluation indicates that the signal conforms to a second mode, the signal is processed as a second mode signal.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: October 13, 2009
    Inventor: Gary Parnes
  • Diagnosis and treatment of disorders of iron metabolism
    Patent number: 7601684
    Abstract: The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron metabolism and to recommend the required treatment and to monitor the progress and response to treatment.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: October 13, 2009
    Assignee: Roche Diagnostics Corporation
    Inventors: Ralf Roddiger, Paul Lehmann, Lothar Thomas
  • Immunomodulatory protein cloned from
    Patent number: 7601808
    Abstract: An immunomodulatory protein is cloned from Ganoderma microsporum. Its molecular weight is 15863.79 Da. Its genome sequence and translated protein sequence are different from those protected by the known patent of glycoprotein LZ-8, which is isolated from the mycelium of G. lucidum and has immunomodulator effect, and its immunomodulator efficiency is better than that of LZ-8.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 13, 2009
    Assignee: World Bio-Tech Alliance Corporation
    Inventor: Tsai-Leng Lin
  • Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
    Patent number: 7598340
    Abstract: A hybridoma (termed “UIC2 hybridoma”, ATCC Accession No. HB11027) producing monoclonal antibodies (termed “UIC2 mAb”) directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a BALB/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdr1 cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: October 6, 2009
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Eugene Metchetner, Igor B. Roninson
  • System and method for chart pattern recognition and analysis in an electronic trading environment
    Patent number: 7599867
    Abstract: A system and method are provided for chart pattern recognition and analysis. In one embodiment, a graphical interface is provided to enable a trader to select a portion of a chart to be used in the chart pattern analysis. The pattern of the selected portion of the chart could then be used to find one or more similar chart patterns in a user-defined timeframe, such as any future time period or a time period in the past. When a reoccurring chart pattern is found in any future time period, an alert signal can be generated to alert a user of a possibility of the chart pattern reoccurrence. Alternatively, chart pattern matches can be found in a time period in the past, and a set of studies can be applied to the found matches to generate a set of reoccurring indicator values. The reoccurring indicator values can be used in combination with the chart pattern to detect any similar chart patterns in the future.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: October 6, 2009
    Assignee: Trading Technologies International, Inc.
    Inventors: Charles Monroe, Alvin F. Tanpoco
  • System and method for quick quote configuration
    Patent number: 7599880
    Abstract: A method and system are described for providing a trader with the ability to quickly configure the quoting side of a trading tool, without experiencing the normal delays associated with conventional methods of quoting. In spread trading, an automated spread trading tool may automatically work an order to buy or sell a tradeable object. A user may configure the trading tool to work an order in a certain tradeable object first. The system allows the user to essentially on-the-fly configure the trading tool to work a second order in another tradeable object, and in response to the change, the system can take specific actions such as deleting the order in the first tradeable object and automatically entering the second order in the other tradeable object. This allows the trader to trade quickly and efficiently.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: October 6, 2009
    Assignee: Trading Technologies International, Inc.
    Inventor: Simon Tam