Abstract: Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a &bgr;-ketoester in the presence of a base.
Type:
Grant
Filed:
July 11, 2002
Date of Patent:
November 4, 2003
Assignee:
Lexicon Pharmaceuticals, Inc.
Inventors:
Hartmuth C. Kolb, Cullen Cavallaro, Zhi-Cai Shi, Alexander Gontcharov, Zhi-Min Wang, Paul F. Richardson, Ramanaiah C. Kanamarlapudi