Abstract: Disclosed are compounds of Formula I:
or the pharmaceutically acceptable salts thereof where, R1, R2, and W are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.
Type:
Grant
Filed:
May 5, 2000
Date of Patent:
July 2, 2002
Assignee:
Neurogen Corporation
Inventors:
Pamela A. Albaugh, Kevin S. Currie, Dan Rosewater, Guolin Cai