Patents Represented by Law Firm Medlen and Carroll, LLP
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Patent number: 8084057Abstract: The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked ?-gal epitopes for induction of recruitment of macrophages localized within or surrounding damaged tissue. The recruited macrophages and stem cells promote the repair and regeneration of the treated injured tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects. In some embodiments, the present invention provides treatments for injured tissues such as brain, peripheral nerve, muscle, cartilage, bone, gastrointestinal tract and dysfunctional endocrine tissues.Type: GrantFiled: August 17, 2009Date of Patent: December 27, 2011Assignee: University of MassachusettsInventor: Uri Galili
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Patent number: 8084219Abstract: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies.Type: GrantFiled: March 17, 2010Date of Patent: December 27, 2011Assignee: The Regents of the University of CaliforniaInventors: Ajit Varki, Pam Tangvoranuntakul, Nissi Varki, Elaine Muchmore
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Patent number: 8080527Abstract: The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compound of any one of Formulae A-E. The invention's methods are useful for the prevention, amelioration, and treatment of autoimmune disease, inflammatory disease, and/or transplant rejection.Type: GrantFiled: July 26, 2010Date of Patent: December 20, 2011Assignee: The Regents of the University of CaliforniaInventor: Michael David
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Patent number: 8076304Abstract: The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1.Type: GrantFiled: April 25, 2005Date of Patent: December 13, 2011Assignee: The Regents of the University of ColoradoInventors: Heide L. Ford, Ricardo D. Coletta, Arthur R. Pardee, Justin Lamb
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Patent number: 8071056Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.Type: GrantFiled: April 29, 2005Date of Patent: December 6, 2011Assignee: The Regents of the University of MichiganInventors: Mark A. Burns, Brian N. Johnson, Michael Chen
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Patent number: 8066981Abstract: The invention relates to compositions and methods related to Toll-like receptor (TLR) polypeptides. In some embodiments, the invention relates to managing TLR3 related diseases. In further embodiments, the invention relates to methods of preventing and treating inflammation. In some embodiments, the invention relates to antagonists of TLR3, to amino acid sequences that act as dominant negative molecules, and to nucleic acid sequences that encode said amino acid sequences. In additional embodiments, the invention relates to the manipulation of biological materials to evaluate TLR3 activity.Type: GrantFiled: November 14, 2007Date of Patent: November 29, 2011Assignee: The Texas A & M University SystemInventors: Cheng C. Kao, Ranjith Kumar Tharachaparamba
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Patent number: 8064127Abstract: This invention relates generally to the field of quasicrystalline structures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for a pre-selected range of wavelengths propagating in multiple directions.Type: GrantFiled: July 7, 2006Date of Patent: November 22, 2011Assignee: The Trustees of Princeton UniversityInventors: Paul Joseph Steinhardt, Paul Michael Chaikin, Weining Man
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Patent number: 8058507Abstract: The present invention relates to compositions and methods for enhancing plant defenses against pathogens. More particularly, the invention relates to enhancing plant immunity against bacterial pathogens, wherein HopM11-300 mediated protection is enhanced, such as increased protection to Pseudomonas syringae pv. tomato DC3000 HopM1 and/or there is an increase in activity of an ATMIN associated plant protection protein, such as ATMIN7. Reagents of the present invention further provide a means of studying cellular trafficking while formulations of the present inventions provide increased pathogen resistance in plants.Type: GrantFiled: February 21, 2008Date of Patent: November 15, 2011Assignee: Board Of Trustees Of Michigan State UniversityInventors: Sheng Yang He, Kinya Nomura
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Patent number: 8034160Abstract: This invention relates to gas generators and methods for their use. In some embodiments, the invention relates to devices and methods of generating a gas enriched in a specific component. In other embodiments, the devices are configured to pressurize and regulate the temperature of atmospheric air prior to passing said air through a selectively permeable gas membrane. In further embodiments, a device is also configured to preheat said selectively permeable gas membrane.Type: GrantFiled: April 25, 2008Date of Patent: October 11, 2011Assignee: Nitro-Lift Technologies, Inc.Inventor: Danny Daniels
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Patent number: 8036997Abstract: The present invention provides methods for classifying data and uncovering and correcting annotation errors. In particular, the present invention provides a self-organizing, self-correcting algorithm for use in classifying data. Additionally, the present invention provides a method for classifying biological taxa.Type: GrantFiled: June 16, 2006Date of Patent: October 11, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: George Garrity, Timothy G. Lilburn
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Patent number: 8017386Abstract: The present invention relates to divinyl ether synthase genes, proteins, and methods of their use. The present invention encompasses both native and recombinant wild-type forms of the synthase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type synthase. The present invention also relates to methods of using divinyl ether synthase genes and proteins, including in their expression in transgenic organisms and in the production of divinyl ether fatty acids, and to methods of suing divinyl ether fatty acids, including in the protection of plants from pathogens.Type: GrantFiled: December 22, 2006Date of Patent: September 13, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: Gregg A. Howe, Aya Itoh
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Patent number: 8017174Abstract: A system and method for recognition of images may include the use of alignment markers. The image recognized may be a pattern from an array, a character, a number, a shape, and/or irregular shapes. The pattern may be formed by elements in an array such as an identification marking and/or a sensor array. More particularly, the system and method relate to discriminating between images by accounting for the orientation of the image. The size and/or location of alignment markers may provide information about the orientation of an image. Information about the orientation of an image may reduce false recognitions. The system and method of image recognition may be used with identification markings, biosensors, micro-fluidic arrays, and/or optical character recognition systems.Type: GrantFiled: October 31, 2007Date of Patent: September 13, 2011Assignee: Board of Regents The University of Texas SystemInventors: Jason E. Meiring, Timothy B. Michaelson, C. Grant Willson
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Patent number: 8010193Abstract: This invention provides a method to discriminate between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following antitachycardia pacing. Also disclosed is an implantable cardiac defibrillator that is capable of simultaneous atrioventricular anti-tachycardia pacing bursts and detecting an earliest arriving electrical signal. The discrimination capability reduces the incidence of inappropriate shocks from dual-chamber implantable cardiac defibrillators to near zero and provides a method to differentially diagnose supraventricular tachycardia from ventricular tachycardia.Type: GrantFiled: November 20, 2003Date of Patent: August 30, 2011Assignee: University of Pittsburgh-of The Commonwealth System of Higher EducationInventor: Samir F. Saba
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Patent number: 8003314Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.Type: GrantFiled: April 16, 2009Date of Patent: August 23, 2011Assignee: Diagnostic Hybrids, Inc.Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, Jr., Ronald Lollar
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Patent number: 7985889Abstract: The present invention relates to compositions and methods for enhancing plant defenses against pathogens. More particularly, the invention relates to enhancing plant immunity against bacterial pathogens, wherein AtMIN7 mediated protection is enhanced and/or there is a decrease in activity of an AtMIN7 associated virulence protein such as a Pseudomonas syringae pv. tomato DC3000 HopM1. Reagents of the present invention provide a means of studying cellular trafficking while formulations of the present inventions provide increased pathogen resistance in plants.Type: GrantFiled: February 21, 2008Date of Patent: July 26, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: Sheng Yang He, Kinya Nomura
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Patent number: 7981291Abstract: The invention relates to a method for the treatment of an aqueous waste stream, wherein: (a) an aqueous waste stream is separated into an effluent and waste sludge; and (b) the waste sludge is converted into predated waste sludge in a predation reactor, the predation reactor including a support comprising worms and the waste sludge being fed past the support comprising worms. The invention further relates to an plant in which the method may be carried out, in particular to an plant for the treatment of an aqueous waste stream that comprises a predation reactor having a support comprising worms, wherein the predation reactor has two compartments that are separated by the support comprising worms.Type: GrantFiled: May 15, 2006Date of Patent: July 19, 2011Assignee: Stichting WetsusInventors: Hellen J. H. Elissen, Bastain R. Buys, Wilhelmus H. Rulkens, Bernard G. Temmink
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Patent number: 7981596Abstract: The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention.Type: GrantFiled: August 25, 2006Date of Patent: July 19, 2011Assignee: The United States of America as represented by the Department of Veteran's AffairsInventors: Hemant Thatte, Kunda Biswas, Shukri Khuri, Thomas Michel
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Patent number: 7981215Abstract: Single crystal MoO3 nanowires were produced using an electrospinning technique. High resolution transmission electron microscopy (HRTEM) revealed that the 1-D nanostructures are from 10-20 nm in diameter, on the order of 1-2 ?m in length, and have the orthorhombic MoO3 structure. The structure, crystallinity, and sensoric character of these electrostatically processed nanowires are discussed. It has been demonstrated that the non-woven-network of MoO3 nanowires exhibits higher sensitivity and an n-type response to NH3 as compared to the response of a sol-gel based sensor.Type: GrantFiled: May 22, 2007Date of Patent: July 19, 2011Assignee: The Research Foundation of State University of New YorkInventors: Pelagia-Irene Gouma, Aisha Suzette Haynes, Krithika Kalyanasundaram
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Patent number: 7977535Abstract: The present inventions relate to compositions and methods for providing stress tolerant transgenic plants comprising a RING domain zinc-finger motif transcription factor protein. More particularly, the invention relates to compositions and methods comprising a RING-H2 domain transcription factor protein for providing drought and salt tolerant plants, in particular comprising a recombinant XERICO gene and protein.Type: GrantFiled: July 12, 2006Date of Patent: July 12, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: Kyung-Hwan Han, Jae-Heung Ko
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Patent number: 7977071Abstract: The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.Type: GrantFiled: June 2, 2005Date of Patent: July 12, 2011Assignee: Adalta Pty Ltd.Inventors: Stewart Nuttal, Victor Streltsov, Katherine Merne Griffiths, Jennifer Ann Carmichael, Peter Hudson, Robert Alexander Irving, Joseph Noozhumurry Varghese, Miles Mackay Barraclough, David Peter Simmons, Kylie Anne Henderson