Patents Represented by Attorney, Agent or Law Firm Medlen & Carroll, LLP
  • Patent number: 8329980
    Abstract: The invention relates to the production of proteins and other substances of interest in saliva of transgenic animals, particularly in mammals that produce large quantities of saliva, particularly monogastric ruminants, and ovine, caprine and bovine mammals. Preferred embodiments of the invention relate in particular to the production of foreign and modified proteins in the transgenic saliva of these animals, including particularly human fibrinogen, human prothrombin and human thrombin, among others. The invention relates as well to methods, devices, genetic constructs and to transgenic constructs for making the proteins and other substances of interest, to novel saliva and saliva-derived compositions, novel products produced from the saliva, and to uses of the saliva, saliva-derived compositions and novel products.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 11, 2012
    Inventor: Jeffrey P. Erickson
  • Patent number: 8314068
    Abstract: The present invention demonstrates that P2X7 receptor induced apoptosis may be specific for cancerous cells. Treatment with the P2X7 ligand BzATP, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects. In mice treated with DMBA/TPA, BzATP decreased papilloma skin formation. BzATP also induced involution of developed papillomas and stimulated apoptosis in keratinocytes outgrowing at the base of developed papillomas. These data show that (a) P2X7 regulates apoptosis of epidermal cells; (b) in vivo, local administration of a drug that activates the P2X7 receptor can inhibit development and progression of epidermal premalignant lesions.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: November 20, 2012
    Assignee: University Hospitals of Cleveland
    Inventors: George Gorodeski, Wen Fu
  • Patent number: 8304712
    Abstract: The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: November 6, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Vera Gorfinkel, Michael Gorbovitski, Andriy Tsupryk
  • Patent number: 8293879
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: October 23, 2012
    Assignee: Diagnostic Hybrids, Inc.
    Inventor: James L. Brown
  • Patent number: 8293927
    Abstract: The present invention relates to methods for the synthesis of morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: October 23, 2012
    Assignee: Board of Regents the University of Texas System
    Inventors: Philip D. Magnus, Benjamin P. Fauber, Neeraj Sane
  • Patent number: 8288098
    Abstract: This invention relates to agents and conjugates to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 16, 2012
    Assignee: AmberGen, Inc.
    Inventors: Kenneth J. Rothschild, Sanjay M. Sonar, Jerzy Olejnik
  • Patent number: 8278045
    Abstract: This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Preferred markers are dipyrrometheneboron difluoride (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)dyes.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: October 2, 2012
    Assignee: Ambergen, Inc.
    Inventors: Kenneth J. Rothschild, Sadanand Gite, Jerzy Olejnik
  • Patent number: 8278271
    Abstract: The present invention provides peptides consisting of L- and/or D-amino acids and combinations thereof, which affect platelets by action on the collagen receptor, glycoprotein VI (GPVI). More specifically, however, the peptides act on the GPVI-FcR? signaling complex. The invention also provides lipid and sugar conjugated peptides comprising L- or D-amino acids. The invention still further provides a method of designing of the peptides and lipid- and/or sugar-conjugated peptides comprising L- or D-amino acids. The present invention further relates to the therapy of various disease states involving the use of these peptides and compounds. Specifically, the peptides and compounds are useful in the treatment and/or prevention of a disease or condition involving platelet activation and aggregation, and more particularly, collagen-induced platelet activation and aggregation. They also are useful in the production of medical devices comprising peptide matrices (i.e., for example, cardiovascular stents).
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: October 2, 2012
    Assignee: University of Massachusetts
    Inventor: Alexander B. Sigalov
  • Patent number: 8277112
    Abstract: The invention provides devices and methods for increasing the degree of mixing of fluids, including under conditions of laminar flow and turbulent flow. In one embodiment, mixing of fluids using the invention's devices and methods is increased by splitting the flow of at least one of the fluids into two or more inlet channels. This is optionally followed by further splitting and merging (e.g., using one or more split and merge (SAM) mixer) the fluids.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: October 2, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Siddharth Bhopte, Bruce Murray, Bahgat Sammakia
  • Patent number: 8261747
    Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: September 11, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Gerald C. Smaldone, Lucy B. Palmer
  • Patent number: 8252942
    Abstract: The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-?B.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: August 28, 2012
    Assignee: Board of Trustees of Michigan State University
    Inventors: Jetze Tepe, James Hamby
  • Patent number: 8245708
    Abstract: The present invention provides an improved method and novel devices for treating tracheobronchitis, bronchiectasis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: August 21, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Gerald C. Smaldone, Lucy B. Palmer
  • Patent number: 8247399
    Abstract: Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blood pressure regulation and cancer treatment.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: August 21, 2012
    Assignee: The Regents of the University of California
    Inventor: Pradip K. Mascharak
  • Patent number: 8243362
    Abstract: This invention relates generally to the field of quasicrystalline structures. In preferred embodiments, the structure is heterostructure comprising dielectric materials arranged in two-dimensional space such that the overall structure is more rotationally symmetric than periodic structures. Symmetry may be five-fold or greater than six-fold. Such higher rotational symmetries provide stopgaps in nearly all directions. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for a pre-selected range of wavelengths propagating in multiple directions.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: August 14, 2012
    Assignee: The Trustees Of Princeton University
    Inventors: Paul Joseph Steinhardt, Paul Michael Chaikin, Weining Man
  • Patent number: 8236500
    Abstract: The present invention is directed to methods and compositions related to ?7 acetylcholine nicotinic receptor genes, in particular, the human ?7 nicotinic acetylcholine receptor gene. The human ?7 nicotinic acetylcholine receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal ?7 alleles, as well as methods and compositions for development of therapeutics.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: August 7, 2012
    Assignee: The United States of America, as represented by the Department of Veterans Affairs
    Inventors: Sherry Leonard, Robert Freedman
  • Patent number: 8239013
    Abstract: The present invention includes a system and method for computerized analysis of a patient's electroencephalogram (EEG) recorded by electrodes placed on the scalp, for the purpose of predicting patient response to medications and therapeutic agents commonly used in psychiatric practice. The prediction of the responses to medications (adverse, no effect, favorable outcome) is an important problem in the clinical practice of psychiatry. A growing number of therapeutic agents are available to the clinician but these agents generate variable responses when prescribed based solely on the patient's history and current symptoms. The present invention is used by physicians to improve patient outcome by selecting agents most likely to be effective for a given patient, using a standardized analysis of the digitized EEG and comparison of individual patient EEC data to a particular database of similar patients whose clinical outcome to pharmacotherapy is known.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: August 7, 2012
    Assignee: CNS Response, Inc.
    Inventors: Stephen C. Suffin, W. Hamlin Emory
  • Patent number: 8237022
    Abstract: The present invention relates to compositions and methods for providing aphid resistance in plants. More particularly, the invention relates to compositions and methods for using aphid resistant germplasm for breeding soybean aphid resistant soybean plants, including but not limited to cultivars, varieties, lines and methods of breeding the same for commercial use, the breeding methods further involving identifying and using genetic markers for aphid resistant traits.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: August 7, 2012
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dechun Wang, Clarice Mensah, Christina D. DiFonzo
  • Patent number: 8232448
    Abstract: This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: July 31, 2012
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Anna Maria Hedlund, Dzung Nguyen
  • Patent number: 8231844
    Abstract: The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: July 31, 2012
    Assignee: The Research Foundation Of State University Of New York
    Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski
  • Patent number: 8227662
    Abstract: The present invention relates to compositions and methods for providing and using markers of aphid resistant germplasm, particularly for identifying aphid resistance germplasm in soybean plants. Specifically, the inventions related to providing aphid resistant germplasm identified by markers associated with decreased damage from aphid feeding, as well as enhanced tolerance to aphid infestation of soybean plants. More particularly, the invention relates to compositions and methods for using genetic markers in breeding methods for producing plants with increased resistance to aphid damage and tolerance, while retaining and acquiring desired agronomic traits, Furthermore, the invention relates to plants produced by these breeding programs for use in commercial soybean production.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: July 24, 2012
    Assignee: Board Of Trustees Of Michigan State University
    Inventors: Dechun Wang, Clarice Mensah, Christina DiFonzo, Guorong Zhang, Menghan Liu, Zhenyu Yang