Patents Represented by Attorney, Agent or Law Firm Medlen & Carroll, LLP
  • Embryonic stem cell self maintenance and renewal reporter
    Patent number: 7662941
    Abstract: The present invention relates to methods and compositions for assaying embryonic stem cell maintenance. In particular, the present invention provides reporter constructs for stem cell pluripotency and differentiation and cells and organisms containing such constructs.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 16, 2010
    Assignee: The Trustees of the University of Princeton - Princeton University
    Inventors: Ihor R. Lemischka, Christoph Schaniel, Feng Li, Xenla Schafer, Patrick J. Paddison
  • ADS genes for reducing saturated fatty acid levels in seed oils
    Patent number: 7655833
    Abstract: The present invention relates to enzymes involved in lipid metabolism. In particular, the present invention provides coding sequences for Arabidopsis Desaturases (ADS), the encoded ADS polypeptides, and methods for using the sequences and encoded polypeptides, where such methods include decreasing and increasing saturated fatty acid content in plant seed oils.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: February 2, 2010
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Ingo H. Heilmann, John Shanklin
  • Treatment of disease by inducing cell apoptosis
    Patent number: 7655472
    Abstract: The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: February 2, 2010
    Assignees: The United States of America as represented by the Department of Veterans Affairs, The Regents of the University of California
    Inventors: Mario Chojkier, Martina Buck
  • Image and part recognition technology
    Patent number: 7651850
    Abstract: A system and method for recognition of images may include the use of alignment markers. The image recognized may be a pattern from an array, a character, a number, a shape, and/or irregular shapes. The pattern may be formed by elements in an array such as an identification marking and/or a sensor array. More particularly, the system and method relate to discriminating between images by accounting for the orientation of the image. The size and/or location of alignment markers may provide information about the orientation of an image. Information about the orientation of an image may reduce false recognitions. The system and method of image recognition may be used with identification markings, biosensors, micro-fluidic arrays, and/or optical character recognition systems.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: January 26, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jason E. Meiring, Timothy B. Michaelson, C. Grant Willson
  • Multi-substituted imidazolines and method of use thereof
    Patent number: 7652056
    Abstract: A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma etc.), antibacterial agents and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-?B as well as potent activity against the Gram (+) bacterium B. subtillus and B. cereus with MIC values in the range of 50 ?m/mL.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: January 26, 2010
    Assignee: Board of Trustees of Michigan State University
    Inventors: Jetze J. Tepe, Satyamaheshwar Peddibhotla
  • Nucleic acid compositions conferring altered metabolic characteristics
    Patent number: 7635798
    Abstract: This invention encompasses the identification and isolation genes and gene fragments that confer altered metabolic characteristics in Nicotiana benthamiana plants, when expressed using GENEWARE™ viral vectors. These genes are derived from a variety of sources. Expression of these genes resulted in alterations of the levels of at least one of the following metabolites: acids, fatty acids, amino acids and related compounds, branched fatty acids, carbohydrates, hydrocarbons, alkaloids and other bases, esters, glycerides, phenols and related compounds, alcohols, alkenes and alkynes, sterols, oxygenated terpenes, and other isoprenoids, and ketones and quinones.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: December 22, 2009
    Assignee: Dow Agrosciences, LLC
    Inventors: Thaddeus Weglarz, Daniel Gachotte, Beth Blakeslee, Ignacio Larrinua, David A. McCrery, Randy J. Pell, J. Vincent B. Oriedo, Barbara A. Miller, Avutu S. Reddy, Vipula Shukla, Rodney Crosley
  • Methods for enhancing plant resistance to pathogens
    Patent number: 7622631
    Abstract: The present invention relates to methods of producing transgenic plants having resistance to blast fungus and/or leaf-blight bacteria by transforming the plants with a DNA encoding a protein that induces hypersensitive reaction-like lesion mimic, and transgenic plants, plant cells, seed and progeny having resistance to blast fungus and/or leaf-blight bacteria.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: November 24, 2009
    Assignee: National Institute of Agrobiological Sciences
    Inventors: Masaki Mori, Kazuhiko Sugimoto, Hirohiko Hirochika, Shoshi Kikuchi, Nagao Hayashi, Hirokazu Ochiai
  • Device to lavage a blood vessel
    Patent number: 7611830
    Abstract: The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. The present invention also provides a device for perfusing tissues and organs with the solutions of the present invention.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: November 3, 2009
    Assignee: The United States of America as represented by the Department of Veteran's Affairs
    Inventors: Hemant Thatte, Kunda Biswas, Shukri Khuri, Thomas Michel
  • Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof
    Patent number: 7608699
    Abstract: The present invention provides novel peptides, nucleic acids, vectors, compounds, compositions and methods for regulating nuclear import. The present invention also relates to a lentiviral NLS, and methods of use thereof for inhibiting HIV pathogenesis and disease progression, and for gene delivery methods.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: October 27, 2009
    Assignee: Rockefeller University
    Inventors: Mark A. Muesing, Tshaka J. Cunningham
  • Methods, devices and formulations for targeted endobronchial therapy
    Patent number: 7607436
    Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: October 27, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Gerald C. Smaldone, Lucy B. Palmer
  • Photocleavable isotope-coded affinity tags
    Patent number: 7595198
    Abstract: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in vivo and in vitro sources. Agents comprise a detectable group bound to a photoreactive group. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: September 29, 2009
    Assignee: Ambergen, Inc.
    Inventors: Jerzy Olejnik, Kenneth J. Rothschild
  • Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
    Patent number: 7582623
    Abstract: Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blood pressure regulation and cancer treatment.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: September 1, 2009
    Assignee: The Regents of the University of California
    Inventor: Pradip K. Mascharak
  • Tissue engineering scaffolds
    Patent number: 7575759
    Abstract: The present invention relates to methods and compositions for the production of scaffolds, such scaffolds to be used for a variety of purposes, including tissue engineering. More specifically, the present invention relates to the use of fused crystals, such as fused salt crystals to form a framework. The methods for producing the scaffolds of this invention improve the porosity, interconnectivity and ease of manufacture as compared to prior art methods.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: August 18, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: William L. Murphy, Robert G. Dennis, David J. Mooney
  • Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
    Patent number: 7575856
    Abstract: The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: August 18, 2009
    Assignees: The United States of America as represented by the Department of Veterans Affairs, President and Fellows of Harvard College
    Inventors: Shukri Khuri, Hemant Thatte, Vladimir Birjinuik
  • Promoter variants of the alpha-7 nicotinic acetylcholine receptor
    Patent number: 7572580
    Abstract: The present invention is directed to methods and compositions related to ?7 acetylcholine nicotinic receptor genes, in particular, the human ?7 nicotinic acetylcholine receptor gene. The human ?7 nicotinic acetylcholine receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal ?7 alleles, as well as methods and compositions for development of therapeutics.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: August 11, 2009
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventors: Sherry Leonard, Robert Freedman
  • Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
    Patent number: 7563617
    Abstract: The invention provides recombinant vectors including adenovirus/adeno-associated virus (Ad/AAV) vectors and mini-adenovirus (mAd) vectors. Further, the invention provides cells containing these vectors, and methods for making and using the vectors and cells. The compositions and methods of the invention are useful in transferring nucleotide sequences of interest into a cell, including, but not limited to, in gene therapy applications.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: July 21, 2009
    Assignee: The Research Foundation Of State University of New York
    Inventors: Patrick Hearing, Wadie F. Bahou, Ziv Sandalon, Dmitri V. Gnatenko
  • Detection of truncation mutations by mass spectrometry
    Patent number: 7563598
    Abstract: This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: July 21, 2009
    Assignee: Ambergen, Inc.
    Inventors: Alex Garvin, Sadanand Gite, Vladislav Bergo, Kenneth Rothschild
  • Compositions for regulation of tumor necrosis factor-alpha
    Patent number: 7560265
    Abstract: The present invention relates to compositions relating a nucleic acid encoding an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides vectors for expressing proteins useful for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: July 14, 2009
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Soo-Hyun Kim, Charles A. Dinarello, Tania Azam
  • Allelic series of genomic modifications in cells
    Patent number: 7554004
    Abstract: The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.) to introduce modifications in any nucleic acid sequence in the genome of a cell. Also provided are sets of cells which contain at least one modification in any gene of interest. The methods and compositions of the invention are useful in determining the function of the gene of interest.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: June 30, 2009
    Assignee: Case Western Reserve University
    Inventors: Richard P. Woychik, Terry R. Magnuson, Ellis D. Avner
  • Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
    Patent number: 7547530
    Abstract: Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide conjugates are described. Such photocleavable markere nucleotides can be incorporated into nucleic acid so as to create photocleavable marker-polynucleotide conjugates.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: June 16, 2009
    Assignee: AmberGen, Inc.
    Inventors: Jerzy Olejnik, Edyta Krzymanska-Olejnik, Kenneth J. Rothschild