Patents Represented by Attorney, Agent or Law Firm Megan F. Williams, Esq.
  • Methods of reducing microbial resistance to drugs
    Patent number: 6677133
    Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: January 13, 2004
    Assignee: Trustees of Tufts College
    Inventors: Margaret Oethinger, Stuart B. Levy