Abstract: Disclosed is a method for treating and preventing bone loss in patients by administering a formulation of anhydrous alendronate sodium. Also described is a pharmaceutical dosage form of said anhydrous alendronate sodium, being anhydrous 4-amino-1-hydroxy-butylidene-1,1-bisphosphonic acid, monosodium salt, in a pharmaceutically acceptable excipient.
Type:
Grant
Filed:
December 3, 1997
Date of Patent:
December 15, 1998
Assignee:
Merck & Co., Inc.
Inventors:
Gerald S. Brenner, Drazen Ostovic, Earl R. Oberholtzer, Jr., J. Eric Thies