Patents Represented by Attorney Melvin Winkokur
  • Patent number: 5631269
    Abstract: Compounds of formula (I) ##STR1## wherein one of X and Y represents nitrogen, and the other of X and Y represents oxygen, sulphur or N--R.sup.2 ; Q represents a substituted five- or six- membered monocyclic heteroaliphatic ring which contains one nitrogen atom as the sole heteroatom and is linked to the five-membered heteroatomic ring containing the moieties X and Y via a carbon atom; as well as substituted 1,3-dioxopropane precursors thereto, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular schizophrenia.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: May 20, 1997
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Howard B. Broughton, Ian J. Collins, Raymond Baker, Paul D. Leeson, Michael Rowley