Patent number: 6610692
Abstract: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:
or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N;
d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independently hydrogen, C1-4 alkyl, or halogen; Y1 and Y2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y3 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, —CN, NH2, OH or C1-4 alkoxy;
A is
and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.
Type:
Grant
Filed:
October 28, 1999
Date of Patent:
August 26, 2003
Assignee:
Merck & Co., Inc.
Inventors:
Philip E. Sanderson, Bruce D. Dorsey, Terry A. Lyle, Matthew G. Stanton, Donnette Staas, Adel M. Naylor-Olsen, Craig Coburn, Matthew M. Morrissette