Abstract: Scopolamine is a folksy cholinergic antagonist, and is used by parasympathetic nerves in autonomic nervous neurons as an anti-motion sickness drug or an anti-emesis drug. Since the human body most effectively absorbs this drug through the postauricular skin, the drug is administered by postauricular transdermal resorption patch. The penetrability of drug is increase by adding a dermal penetrative enhancer, because the penetration ability of patch-administered drugs is usually decreased by the penetrative blockade at dermal horny layers. The present invention discloses a penetration enhancer to increase dermal absorption and penetration of the cholinergic antagonist. The present invention finds that polyethylene and amide enhance penetration, about 2.2-2.8 fold. In accordance with the present invention, a penetration enhancer is added to the formulations of transdermal patch to increase the human body's absorption of scopolamine.

Abstract: The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting selected amino acid segments of the polypeptide with an analogous polypeptide segment from an analog to the polypeptide. The analog has a different activity with the target substance as compared to the parent polypeptide. The activities of the segment-substituted polypeptides are compared to the same activity for the parent polypeptide for the target. A comparison of such activities provides an indication of the location of the active domain in the parent polypeptide. The invention also provides methods for identifying the active amino acid residues within the active domain of the parent polypeptide.

Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

Abstract: A chain link (1) consists of two loops (2a, 2b) and two sides (3a, 3b), and a post (5) welded in between the chain link's sides (3a, 3b). The post (5) has sections (7) of reduced thickness against the chain link's sides (3a, 3b) in order to produce weld grooves for welding the post (5) to the chain link's sides (3a, 3b) with a through-weld. A sacrificial anode (9) is affixed around the chain link's post (5), by means of casting, welding or clamping.

Abstract: An apparatus and method are described for removing particulate matter from one or more surfaces of a workpiece, such as a credit card blank, prior to printing a graphic design thereon. The apparatus includes a pair of cleaning rollers which engage both sides of the card, the cleaning rollers having an adhesive coating for removing loose particulate matter from the surfaces of the card. The apparatus also includes a stripper system for stripping collected particulate matter away from the cleaning rollers after a predetermined number of cards have been cleaned.

Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.

Abstract: A multiple exercise unit capable of providing a user with a wide range of strength and conditioning exercises. The exercise unit provides resistance through an isokinetic device which utilizes a clutch mechanism. Lines extend out of the isokinetic device and attach to various exercise elements such that a variety of upper and lower body strength exercises may be performed.

Abstract: There is disclosed an air conditioning unit for location in the wall of a room and which comprises a heat exchanger, an external supply fan operable to blow air into the room through the heat exchanger and an extract fan operable to draw air out of the room through the heat exchanger, in which the heat exchanger comprises a stack of thin flexible plates which are spaced apart from each other so as to define between opposed faces of adjacent plates extract air flow paths and supply air flow paths through the heat exchanger, with the spacing apart of the faces defining the extract air flow paths being greater than the spacing apart of the faces defining the supply air flow paths whereby the depth of the extract air flow paths initially is greater than the depth of the supply air flow paths, but during operation any tendency for the flexible plates to deform under differential pressure action results in the depths of the extract air flow paths and supply air flow paths being substantially equalized, which provid

Abstract: An aspirating foamer having a water inlet path to admit water into the nozzle assembly, two diametrically opposed foaming material inlet paths perpendicular to the water inlet path, and a conical conduit wherein the pressurized water and foaming materials mix and are allowed to expand; and an air inlet valve at the exiting end of the conical conduit for admitting air; and an exiting path for the foam. In one foamer (2) the conical conduit has an outwardly tapered angle of approximately 5 degrees (from centerline) initially with an immediate increase to an outwardly tapered angle of about 7 degrees in the second half of the conical conduit. In another embodiment foamer (102) according to the invention the conical conduit has an initial taper of 21/2 degrees followed by a 15 degree diffusion angle and then a 7 degree angle.

Abstract: A method and apparatus are disclosed for providing a crimp seal pleated filter assembly having a two piece housing with a filter media disposed within the housing and having a plurality of alternating pleats. The apparatus includes a first and second jig for supporting the housing halves and an odd number of at least three or more movable pleat forming blades on one side of the apparatus. The odd number of blades are movable through one of the supporting jigs with blade edges opposing the other supporting jig. The odd number of blades includes an independently movable center blade and a first pair of outer blades with opposing surfaces of adjacent blades defining a first plurality of pleat forming spaces. An even number of pleat forming blades are positioned with blade edges opposing the first plurality of pleat forming spaces and are spaced apart from and in alignment with the opposing pleat forming blades.

Abstract: An endotracheal tube (10) including, in addition to a primary ventilating channel (11), a secondary speaking channel (12). The speaking channel (12) contains an array of exit ports (16) for the introduction of a tone into the posterior oral pharynx (23) of the intubated patient. This tone is then conducted into the oral cavity (18) wherein it is articulated into speech by the patient. This substitute vocal sound is produced by a tone generating device (19) connected to and in air communication with the speaking channel (12) of the present invention.

Abstract: The present invention relates to an optical sensor apparatus (21) for use in a remote meter monitoring system (20) for remotely monitoring the dials (34) of a utility meter or the like by use of a liquid crystal display (31). The liquid crystal display (31) includes five distinct areas 71 through 75 arranged in a semicircle in register with the circumferential path of a dial pointer arrangement (36) of the meter which including a dial pointer (37) and a disk like member (38) having a light absorptive semicircular portion (38a) and a reflective semicircular portion (38b). A sixth distinct area (76) being positioned in a diametrically opposed semicircle. The disk like member (38) being illuminated by a light emitting diode (40).