Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Abstract: This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.

Abstract: A wireless telephone backup device for landline telephone equipment that may be located on the customer side of the landline service connection, typically in a restricted access location, such as an attic, basement, or utility closet. An interconnection circuit in the backup device detects service interruptions in the subscriber's landline connection and, in response, powers on a wireless communication device to provide backup telephone service to the customer premises equipment. The interconnection circuit also provides the other features standard landline telephone service, including dial tone, ring voltage, and normal dialing for outgoing calls. The backup device also forwards incoming landline calls to the wireless unit in the backup device, and may send a message notifying a maintenance center of the service interruption. Further, the backup device may initiate an indicator in an alarm system at the site of the customer premises equipment to notify the subscriber of the service interruption.