Patents Represented by Attorney, Agent or Law Firm Mervin E. Brokke
  • Use of droloxifene for the treatment of protastic disease, endometriosis and obesity
    Patent number: 5852059
    Abstract: This invention provides a method for treating a condition or disease selected from endometriosis, obesity, benign prostatic hypertrophy and prostatic carcinoma in mammals which comprises administering to said mammal an amount of droloxifene or a pharmaceutically acceptable salt thereof which is effective in treating said condition or disease.
    Type: Grant
    Filed: January 6, 1997
    Date of Patent: December 22, 1998
    Assignee: Pfizer Inc.
    Inventor: David D. Thompson
  • 2,7-substituted octahydro-1H-pyrido?1,2-a!pyrazine derivatives
    Patent number: 5852031
    Abstract: Substituted pydrido?1,2-a!pyrazines of general formula I wherein Ar and Ar.sup.1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO.sub.2, C.dbd.O, CHOH, or --(CR.sup.3 R.sup.4) and n is 0-2 as well as precursors thereto are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: December 22, 1998
    Assignee: Pfizer Inc.
    Inventors: Kishor A. Desai, Anton F. J. Fliri, Mark A. Sanner
  • Use of droloxifene for the treatment of cardiovascular diseases
    Patent number: 5827892
    Abstract: Use of droloxifene in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: March 13, 1996
    Date of Patent: October 27, 1998
    Assignee: Pfizer Inc.
    Inventors: Roland Loser, Michael Schliack, David D. Thompson
  • Methods for alleviating symptoms of premenstrual syndrome and late luteal phase dysphoric disorder
    Patent number: 5733937
    Abstract: The present invention provides novel methods of inhibiting the symptoms of premenstrual syndrome comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: March 31, 1998
    Assignee: Pfizer Inc.
    Inventors: David B. MacLean, David D. Thompson
  • Protection of ischemic myocardium against reperfusion damage
    Patent number: 5726207
    Abstract: The present invention provides novel methods of inhibiting reperfusion damage in ischemic myocardium comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: March 10, 1998
    Assignee: Pfizer Inc.
    Inventors: David B. MacLean, David D. Thompson
  • 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease
    Patent number: 5719191
    Abstract: The present invention provides novel methods of inhibiting Alzheimer's Disease comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 17, 1998
    Assignee: Pfizer Inc.
    Inventors: David B. Maclean, David D. Thompson
  • Inhibition of myeloperoxidase activity
    Patent number: 5719190
    Abstract: The present invention provides novel methods of inhibiting myeloperoxidase activity comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 17, 1998
    Assignee: Pfizer Inc.
    Inventors: David B. MacLean, David D. Thompson
  • Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents
    Patent number: 5607959
    Abstract: Compounds of formula (I) where R.sup.1 is thienyl, phenyl or furyl, X and Y are halogen or hydrogen and Q is alkoxy or amino are useful as analgesic and antiinflamatory agents.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: March 4, 1997
    Assignee: Pfizer Inc.
    Inventor: Ralph P. Robinson
  • Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
    Patent number: 5589482
    Abstract: Benzothiophenes and related compounds of the formula ##STR1## are estrogen agonists which are useful for treating prostatic and diseases, obesity and bone loss in male animals.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: December 31, 1996
    Assignee: Pfizer Inc.
    Inventor: David D. Thompson
  • Process for producing antiparasitic macrolide antibiotics
    Patent number: 5589366
    Abstract: The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions comprising such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: December 31, 1996
    Assignee: Pfizer Inc.
    Inventors: Mark A. Haxell, David A. Perry, Hiroshi Maeda, Junsuke Tone
  • Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds
    Patent number: 5573946
    Abstract: The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions containing such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: November 12, 1996
    Assignee: Pfizer Inc.
    Inventors: Mark A. Haxell, David A. Perry, Hiroshi Maeda, Junsuke Tone
  • 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
    Patent number: 5552412
    Abstract: Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: September 3, 1996
    Assignee: Pfizer Inc
    Inventors: Kimberly O. Cameron, Paul A. Dasilva Jardine, Robert L. Rosati
  • Antiparasitic macrolide antiobiotics
    Patent number: 5510372
    Abstract: The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pest, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions comprising such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: April 23, 1996
    Assignee: Pfizer Inc
    Inventors: Mark A. Haxell, David A. Perry, Hiroshi Maeda, Junsuke Tone
  • Calcium independent camp phosphodiesterase inhibitor antidepressant
    Patent number: 5459145
    Abstract: Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.
    Type: Grant
    Filed: January 19, 1988
    Date of Patent: October 17, 1995
    Assignee: Pfizer Inc.
    Inventors: Nicholas A. Saccomano, Fredric J. Vinick
  • Estrogen agonists as remedies for prostate and cardiovascular diseases
    Patent number: 5441986
    Abstract: Use of droloxifene in the treatment of benign prostatic hyperplasia, prostatic carcinoma and cardiovascular diseases.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: August 15, 1995
    Assignee: Pfizer Inc.
    Inventor: David D. Thompson
  • Method of treating diseases susceptable to treatment by blocking NMDA-receptors
    Patent number: 5436255
    Abstract: 3-Piperidino-1-chromanol derivatives and analogs having the formula ##STR1## wherein A and B are taken together and are --CH.sub.2 CH.sub.2 -- or A and B are taken separately and are each H;X is CH.sub.2 or O;X.sup.1 is H or OH;Z is H, F, Cl, Br or OH;Z.sup.1 is H, F, Cl, Br or (C.sub.1 -C.sub.3)alkyl;n is 0 or 1; andm is 0 or an integer from 1 to 6;pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds are disclosed.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: July 25, 1995
    Assignee: Pfizer Inc.
    Inventor: Todd W. Butler
  • Processes and intermediates for N-(S-3-alkyl-heptanoyl)-D-gamma-glutamyl-glycyl-D-alanine
    Patent number: 5420347
    Abstract: Immunoregulatory N-(S-3-alkyl-4-heptenoyl)- and N-(S-3-alkylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine and esters thereof are synthesized via R-trans-2-hexen-4-ols, R-3-alkyl-4-heptenoic acid and S-3-alkylheptanoic acid.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: May 30, 1995
    Assignee: Pfizer Inc.
    Inventor: Charles W. Murtiashaw
  • Pyrimido-benzothiazines
    Patent number: 5418231
    Abstract: This invention relates to novel pyrimido-benzothiazine derivative compounds. ##STR1## The compounds of the present invention inhibit the action of the lipoxygenase enzyme and are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals. This invention also relates to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: May 23, 1995
    Assignee: Pfizer Inc.
    Inventors: Kaoru Shimada, Yuji Shishido
  • Calcium independent camp phosphodiesterase inhibitor antidepressant
    Patent number: 5414127
    Abstract: Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.
    Type: Grant
    Filed: January 19, 1994
    Date of Patent: May 9, 1995
    Assignee: Pfizer Inc.
    Inventors: Nicholas A. Saccomano, Fredric J. Vinick
  • Thiazolidinedione hypoglycemic agents
    Patent number: 5401761
    Abstract: Compounds of the formula ##STR1## where R is alkyl, cycloalkyl, phenyl or substituted phenyl are useful as hypoglycemic agents.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: March 28, 1995
    Assignee: Pfizer, Inc.
    Inventors: Steven W. Goldstein, Bernard Hulin