Patents Represented by Attorney Michael A. Vinson & Elkins L.L.P. Sanzo
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Patent number: 6136817Abstract: New morphinane derivatives of the formula ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in the manufacture of pharmaceutical preparations.Type: GrantFiled: August 22, 1995Date of Patent: October 24, 2000Assignee: Astra ABInventor: Helmut Schmidhammer
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Patent number: 6117912Abstract: The present invention is directed to improved methods for treating certain selegiline-responsive diseases or conditions and, more specifically, to methods in which selegiline is administered buccally or sublingually. Selegiline may be used ether as a free base or as a pharmaceutically acceptable acid addition salt. The selegiline-responsive diseases or conditions include neuronal-degenerative diseases and conditions, such as Alzheimer's disease and neuronal damage from hypoxia, stroke, ischemia, and trauma, and dopaminergic-related, selegiline responsive diseases and conditions such as depression and ADHD.Type: GrantFiled: April 28, 1998Date of Patent: September 12, 2000Assignee: Somerset Pharmaceuticals, Inc.Inventor: Anthony R. DiSanto
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Patent number: 6077539Abstract: This invention comprises a non-vasoactive, supra-vasoactive syndrome ("SVS") minimized dosage form for treatment of migraine in a human comprising (i) rapid availability metoclopramide in at least about an effective local gastrointestinal amount; (ii) at least one long acting NSAID such as naproxen sodium in a therapeutically effective amount; (iii) wherein said dosage form is a coordinated dosage form; and, (iv) wherein the dosage form is absent 5HT agonist vasoactive agents, and preparation thereof. Acid-base stable dosage forms are noted. This invention further comprises methods of migraine treatment, and methods for rapid introduction of oral NSAID into the small bowel.Type: GrantFiled: November 10, 1997Date of Patent: June 20, 2000Assignee: Pozen, Inc.Inventors: John R. Plachetka, Zakauddin T. Chowhan
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Patent number: 6060499Abstract: This invention comprises a method of treating migraine in a human comprising co-timely administering of a therapeutically effective amount of a 5-HT agonist coordinated with a therapeutically effective amount of an analgesic, particularly a long-acting NSAID, and in some instances, doses below those ordinarily considered as minimum effective doses as to one or both 5-HT agonist and long-acting NSAID. Dosage forms are also included herein.Type: GrantFiled: September 11, 1998Date of Patent: May 9, 2000Assignee: Pozen, Inc.Inventor: John R. Plachetka
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Patent number: 6036935Abstract: The present invention is directed to a process for the production of polyaluminum chlorides and polyaluminum chlorosulfates useful as coagulants in water treatment. In addition, the invention is directed to the products made by the disclosed processes.Type: GrantFiled: December 17, 1998Date of Patent: March 14, 2000Assignee: Delta Chemical CorporationInventor: James M. Dulko
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Patent number: 6033682Abstract: The present invention provides novel compositions and methods for using the S(+) enantiomer of desmethylselegiline (N-methyl-N-(prop-2-ynyl)-2-aminophenylpropane), for the treatment of selegiline-responsive diseases and conditions. Diseases and conditions responsive to selegiline include those produced by neuronal degeneration or neuronal trauma and those due to immune system dysfunction. Effective dosages are a daily dose of at least about 0.015 mg/kg of body weight.Type: GrantFiled: July 12, 1996Date of Patent: March 7, 2000Assignee: Somerset Pharmaceuticals, Inc.Inventor: Anthony R. DiSanto
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Patent number: 6034097Abstract: The present invention is directed to compounds that act as analgesics and that have the structure of formula (I): ##STR1## wherein; Z is ##STR2## wherein, n is 1 or 2, and R.sub.0 is C.sub.6-12 aryl or C.sub.7-8 aralkyl; orR.sub.1 is selected from the group consisting of hydrogen; --NH--C.sub.1-6 alkyl; C.sub.1-6 alkyl; C.sub.6-12 aryl; C.sub.7-18 aralkyl; arginyl; and R.sub.30 NHC(.dbd.NH)--, wherein R.sub.30 is hydrogen, C.sub.6-12 aryl, C.sub.7-18 aralkyl, or C.sub.1-6 alkyl;R.sub.2 is hydrogen; C.sub.1-6 alkyl; or OH;R.sub.3 is C.sub.6-12 aryl; C.sub.7-18 aralkyl; --CH.sub.2 --C.sub.6 H.sub.2 R.sub.8 R.sub.9 ;or --CH.sub.2 --OHC.sub.6 HR.sub.8 R.sub.9, wherein each of R.sub.8 and R.sub.9 is independently, or hydrogen;R.sub.4 C.sub.6-12 aryl; C.sub.7-18 aralkyl; C.sub.1-12 alkyl; or a substituted or unsubstituted cyclohexyl;R.sub.5 is C.sub.1-6 alkyl; hydrogen; OH; halogen; SH; NO.sub.2 ; NH.sub.2 ; --NH--C.sub.1-6 alkyl; NH.sub.2 C (.dbd.NH--; NH.sub.2 C (.dbd.NH)--NH--; COOR.sub.31, wherein, R.sub.Type: GrantFiled: October 6, 1997Date of Patent: March 7, 2000Assignee: Astra ABInventors: John DiMaio, Wuyi Wang
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Patent number: 6031007Abstract: The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.Type: GrantFiled: August 6, 1997Date of Patent: February 29, 2000Assignee: Astra ABInventors: Arne Brodin, Raymond Fynes, Lars Heijl, Adela Nyqvist-Mayer, Marie Scherlund
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Patent number: 6024707Abstract: The present invention provides non-invasive methods for diagnosing Alzheimer's disease in a living human subject. One method employs a non-invasive automated apparatus which can continuously monitor pupil diameter size over time; repetitively measure pupil diameter size over time for a pre-chosen duration ranging from about less than 1 second to about 5 minutes; and cumulatively record size information as it is obtained over time. A second method employs an apparatus which can repetitively measure pupil constriction velocity for a pre-chosen duration both before and after stimulation by visible light. Both methods require the administration of at least one neural transmitter mediator to a targeted eye of the living subject in an amount insufficient to cause marked changes in pupil diameter size over time in a person who is not afflicted with Alzheimer's disease.Type: GrantFiled: September 17, 1997Date of Patent: February 15, 2000Assignee: Beth Israel Deaconess Medical CenterInventors: Leonard Scinto, Kirk R. Daffner
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Patent number: 6017879Abstract: The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.Type: GrantFiled: April 3, 1998Date of Patent: January 25, 2000Assignee: B.M.R.A. Corporation B.V.Inventors: Manfred Mutter, Jean-Silvain Lacroix, Eric Grouzmann
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Patent number: 6009868Abstract: The present invention relates to a spray mouthpiece arranged on the outer free end of a spray tube. The mouthpiece is adapted by means of intersecting flow passages to atomize liquid which is fed to the spray tube under pressure. The arrangement according to the invention comprises an elongated sleeve which is adapted to be carefully placed on the free end of the spray tube. The sleeve is designed with an end face on which is a centrally located mouthpiece opening. In the sleeve is a cylindrical body connecting to the end face. The body has grooves with which the sleeve forms at least two ducts communicating with the tube. From the tube end, the ducts run approximately axially up to the end face. By means of the intersecting flow passages formed on the end face of the body, the ducts are connected to a chamber that connects to the mouthpiece opening.Type: GrantFiled: October 2, 1996Date of Patent: January 4, 2000Assignee: Astra ABInventor: Billy Nilson
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Patent number: 5997838Abstract: The present invention is directed to a process for the production of polyaluminum chlorides and polyaluminum chlorosulfates useful as coagulants in water treatment. In addition, the invention is directed to the products made by the disclosed processes.Type: GrantFiled: December 17, 1998Date of Patent: December 7, 1999Assignee: Delta Chemical CorporationInventor: James M. Dulko
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Patent number: 5994327Abstract: A process for the preparation of 14-alkoxyindolomorphinans and 14-alkoxybenzofuranomorphinans is disclosed. The process facilitates the preparation of a large variety of 14-alkoxy substituted indolomorphinans and benzofuranomorphinans in which a 3-hydroxy substituent is present.Type: GrantFiled: March 13, 1997Date of Patent: November 30, 1999Assignee: Astra ABInventors: Helmut Schmidhammer, Peter Schwarz, Zhong-Yong Wei
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Patent number: 5989542Abstract: The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced by this purification method and to vaccines which utilize such antigens.Type: GrantFiled: August 17, 1998Date of Patent: November 23, 1999Assignee: Brigham and Women's Hospital, Inc.Inventors: Gerald B. Pier, Johannes Huebner, Ying Wang, Lawrence Madoff
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Patent number: 5985234Abstract: The present invention is directed to a process for the production of polyaluminum chlorides and polyaluminum chlorosulfates useful as coagulants in water treatment. In addition, the invention is directed to the products made by the disclosed processes.Type: GrantFiled: August 25, 1997Date of Patent: November 16, 1999Assignee: Delta Chemical CorporationInventor: James M. Dulko
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Patent number: 5972650Abstract: The present invention is directed to DNA constructs suitable for gene expression in mammalian cells and which are characterized by the presence of a mammalian promoter under the control of a tet operator/repressor system. The DNA may be used as part of a system for expressing recombinant protein. In addition, the tet operator/repressor system can be used to engineer cis- and trans-destructive viruses which are capable of replicating in the presence of the tet repressor, but not in the absence of the repressor. These viruses can be used either directly in the treatment of patients with corresponding viral diseases, as vehicles for the delivery of nucleic acids that can serve as therapeutic agents and as part of vaccines designed to immunize people or animals against viral diseases.Type: GrantFiled: June 26, 1997Date of Patent: October 26, 1999Assignee: Brigham and Women's HospitalInventor: Feng Yao
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Patent number: 5968953Abstract: New compounds of the formula (A) ##STR1## a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.Type: GrantFiled: April 22, 1998Date of Patent: October 19, 1999Assignee: Astra ABInventors: Anna-Lena Ask, Lars-Inge Olsson, Rune Sandberg
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Patent number: 5919460Abstract: The present invention is directed to a composition that can be used in alleviating symptoms associated with chronic fatigue syndrome or acquired immune deficiency syndrome. The composition is derived from the herbs Chimaphila umbellate, Apocynum andro-saemifolium, Symphytum officianale, and Equisetum hyemale. In addition, the invention is directed to a method of treating patients using this composition.Type: GrantFiled: January 28, 1998Date of Patent: July 6, 1999Inventor: Teresa J. Ingram
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Patent number: 5912271Abstract: A new pharmaceutical preparation comprising one or more local anaesthetic agents, a polar lipid, a triacylglycerol and optionally water. The new pharmaceutical preparation is excellent for topical treatment of pain.Type: GrantFiled: September 18, 1995Date of Patent: June 15, 1999Assignee: Astra ABInventors: Arne Brodin, Anders Carlsson, Bengt Herslof, Martin Nicklasson, Lisbeth Rydhag
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Patent number: 5908847Abstract: New combination of a .beta.-receptor blocker or a pharmaceutically acceptable salt thereof, and an opioid or a pharmaceutically acceptable salt thereof, optionally in the presence of a pharmaceutically acceptable carrier or any additional agents which may be active or inactive. The new combination confers a synergistic effect, and provides unexpected efficacy in the treatment of pain.Type: GrantFiled: January 2, 1997Date of Patent: June 1, 1999Assignee: Astra ABInventor: Arne Eek