Patents Represented by Attorney Michael C. Schiffer
  • Patent number: 7368082
    Abstract: This invention relates to spotting solutions for the production of assay articles with uniform spot size and morphology for the detection of biopolymers, comprising N-lauroyl sarcosine in a buffered solution. Optionally the spotting solution may further comprise a fluorophore or a dye. This invention further provides means for non-destructive quality control of the production of said assay articles. This invention further provides means for non-destructive quality control of the production of said assay articles.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: May 6, 2008
    Inventors: Tung-Lian Huang, Daniel Keys, M. Parameswara Reddy
  • Patent number: 7358094
    Abstract: An analytical system for detecting a saccharide is provided. The analytical system includes a saccharide sensor attached to a solid substrate and having the formula: Where Z is selected from the group consisting of hydrogen, alkyl groups, an aryl; N is a nitrogen atom; Bd1 and Bd2 are independently selected binding groups, wherein the binding groups are capable of binding an saccharide; Sp is a spacer; An is an anchor group for attaching the sensor to solid substrate, including a bead; and n=1 or 2, m=1 or 2, y=1 or 2, and p is an integer. In one embodiment the saccharide sensor preferentially detects glucose. The invention further provides beads having the saccharide sensor attached thereto and methods of detecting glucose using the system.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: April 15, 2008
    Inventors: Michael L. Bell, Tony D. James, Susumu Arimori
  • Patent number: 6716004
    Abstract: A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: April 6, 2004
    Assignee: Baxter International Inc.
    Inventors: Mark R Vandlik, Tom Westberg
  • Patent number: 5261887
    Abstract: An integrated catheter stripper is mounted within a modified Y-connector that is used to seal a catheter on a guide wire. The connector is provided with a stripping port that opens into the central bore of the main body of the connector. A catheter slitter is mounted over the guide wire within the central bore of the main body for slitting the catheter as the catheter slides in the proximal direction along the guide wire within the main body. The split catheter is removed through the stripping port, which can be sealed during an angioplasty operation when the catheter is in use.In non-integrated embodiments of the invention the catheter stripper is separate from the Y-connector and has a main body, a blade mounted in the main body, and an arrangement for aligning the catheter with the blade and for permitting mounting and separation of the blade relative to the catheter only by substantially longitudinal movement.
    Type: Grant
    Filed: January 22, 1992
    Date of Patent: November 16, 1993
    Assignee: Baxter International Inc.
    Inventor: Blair D. Walker
  • Patent number: 5236665
    Abstract: A hollow fiber membrane fluid treatment apparatus for the transfer of mass or energy through the membrane is disclosed. It is designed particularly, but not only, for use in membrane oxygenators. Hollow fiber membranes extend substantially longitudinally, first inert fibers are spaced between them and also extend substantially longitudinally. Second inert fibers extend generally transverse to the hollow fibers and generally contiguous therewith, so that a first fluid (preferably an oxygen-containing gas) can pass through the hollow fibers and a second fluid (preferably blood) can be passed over their exterior for mass or energy transfer through the membrane.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: August 17, 1993
    Assignee: Baxter International Inc.
    Inventors: Wilfred F. Mathewson, Philip L. Ritger
  • Patent number: 5225161
    Abstract: A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: July 6, 1993
    Assignee: Baxter International Inc.
    Inventors: Wilfred F. Mathewson, Richard L. Bringham, Philip L. Ritger, David L. Karshmer
  • Patent number: 5204451
    Abstract: The invention relates to a method of binding biologically active organic ligands to hydroxyl groups of polymeric carriers. The method involves bringing 4-fluorobenzenesulfonyl Chloride into reactive contact with the hydroxyl groups of polymeric carriers in such a manner to form sulfonate groups in place of the hydroxyl groups. The ligand is then brought into reactive contact with the hydroxyl groups of polymeric carriers to replace the sulfonate groups reacted with the organic ligand. The polymeric carrier containing the bound ligand can be used to isolate a biologically active material from a heterogeneous solution.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: April 20, 1993
    Assignee: Baxter International Inc.
    Inventor: Yu-An Chang
  • Patent number: 5197979
    Abstract: A stentless aortic heart valve having a disposable holder with a removable handle can be manually reversed by the physician during suturing to provide a relatively unobstructed view into the patient's aorta. A covering applied to strategic regions on the exterior and interior of the device provides a firm ground for suturing the prosthetic heart valve into position, and for attaching the detachable holder.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: March 30, 1993
    Assignee: Baxter International Inc.
    Inventors: Lillian J. Quintero, Delos M. Cosgrove, Diana Nguyen-Thien-Nhon
  • Patent number: 5171299
    Abstract: An apparatus for determining fluid pressure and inflation diameter in the balloon of a dilation catheter includes a pressure sensing transducer in fluid communication with the interior of the catheter balloon. The transducer provides a balloon pressure signal which is processed by a microcomputer to determine a balloon diameter or circumference as a function of the balloon pressure. The microcomputer produces a signal representing the balloon diameter or circumference. A digital display responds to the pressure signal and diameter signal to display both balloon pressure and diameter in order to provide an added degree of safety and control to a vascular physician conducting balloon angioplasty or similar procedures.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: December 15, 1992
    Assignee: Baxter International Inc.
    Inventors: Harold A. Heitzmann, Jeffrey S. Dove, Lauralan T. Grisoni
  • Patent number: 5163911
    Abstract: A catheter system includes a guide wire, a working catheter and a torque device for removably coupling the working catheter to the guide wire while enabling rotation of the guide wire to the working catheter. Advancement of the guide wire in a vascular system is enabled by rotating the guide wire while the working catheter is coupled thereto. A procedure for use of the catheter system includes the simultaneous insertion of the guide wire and working catheter into a vascular system and independent rotation of the guide wire for steering the guide wire, with working catheter coupled thereto, through the vascular system.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: November 17, 1992
    Assignees: Baxter International Inc., Peter Den Heijer, Paul S. Teirstein
    Inventors: D. Laksen Sirimanne, Sandra L. Cutter, Zohrab S. Kemkemian, Peter D. Heijer, Paul M. Teirstein
  • Patent number: 5120502
    Abstract: A membrane oxygenator having a gas pressure relief valve operable to release gas when the gas pressure in the oxygenator exceeds a predetermined level. Generally, the membrane oxygenator includes a housing in which is mounted a gas-permeable, liquid-impermeable membrane, i.e. a bundle of microporous hollow fibers. This membrane defines separate oxygen enrichable fluid and gas flow pathways. The housing also includes both gas and oxygen enrichable fluid inlet and outlet ports communicating with respective opposite ends of the gas and oxygen enrichable fluid flow pathways. The gas pressure relief valve communicates with the gas flow pathway.
    Type: Grant
    Filed: November 21, 1990
    Date of Patent: June 9, 1992
    Assignee: Baxter International Inc.
    Inventors: Lucas Gordon, Victor Ham
  • Patent number: 5110549
    Abstract: A blood oxygenator having a defoaming device for separating foam and bubbles from a liquid, such as blood, is disclosed. The defoaming device of the oxygenator is designed for separating air from blood while minimizing blood contact with the antifoam agent used in the device. In a first embodiment, the device includes a reservoir and a filtering material that does not contain any antifoaming agent. This filtering material is positioned in a lower portion of the reservoir to separate foam and bubbles from the liquid. An element containing an antifoaming agent is positioned in the reservoir above the maximum surface fluid level therein and receives the foam and bubbles that rise from the filtering material. Contact of the liquid with the antifoaming agent is substantially avoided. In a second embodiment, an element containing an antifoaming agent is positioned in the reservoir within the fluid therein.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: May 5, 1992
    Assignee: Baxter International Inc.
    Inventor: Lucas S. Gordon
  • Patent number: 5104407
    Abstract: An annuloplasty ring prosthesis which is formed from a selectively flexible body element having at least one defined length about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material through which sutures can be drawn to suture the prosthesis to the heart valve annulus.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: April 14, 1992
    Assignee: Baxter International Inc.
    Inventors: Hung L. Lam, Than Nguyen, Alain Carpentier
  • Patent number: 5078702
    Abstract: Catheters having tubular body portion formed with an inner sheath of a rigid polymeric material encapsulated by an outer sheath formed of the same or different rigid polymeric material. A wire braid is embedded in the tubular body between the inner and outer sheaths. The catheter further includes a tip portion which is welded to an end of the tubular body portion. This tip portion has an inner sheath of a rigid polymeric material encapsulated by an outer sheath of a flexible polymeric material. The inner sheath of both the body and tip portions are formed from the same polymeric material. The compatibility between the polymeric materials of the inner sheaths substantially increases the bonding between the tip and body portions of the catheter to form a stable joint.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: January 7, 1992
    Assignee: Baxter International Inc.
    Inventor: Mark L. Pomeranz
  • Patent number: 5074845
    Abstract: Disclosed is an everting balloon catheter in which the balloon has a waist at the desired eversion point to minimize the size of the distal tip of the catheter during insertion. Preferably, the distal end of the outer body is bevelled and the waist is located just distal and radial to the tip of the outer body when the inner body is fully extended distal to the outer body. Usually, the waist is formed by heat shrinking the balloon during manufacture, thus usually increasing balloon thickness at the waist.Also, in the disclosed invention, the balloon is attached to the outer catheter bod via heat fusion. Generally, the outer body and the balloon are both formed of compositions having at least one component in common to promote heat fusion for attachment of the balloon. Preferably that component is polyethylene.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: December 24, 1991
    Assignee: Baxter International Inc.
    Inventors: Manouchehr Miraki, Carmen Diaz
  • Patent number: 5071609
    Abstract: Interpenetrated matrix of polytetrafluoroethylene and elastomer is disclosed. The matrix is formed into a composite material which is flexible, durable, highly porous with a tight microporous structure and improved retractability. The composite material is subjected to a multi-expansion process to produce shaped articles such as films, tubes, rods and filaments with excellent flexibility and elasticity. More particularly, the composite material can be utilized to produce vascular grafts with excellent biological compatibility.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: December 10, 1991
    Assignee: Baxter International Inc.
    Inventors: Roger H. Tu, Wilfred F. Mathewson, Mark A. Roberts
  • Patent number: 5067962
    Abstract: A xenograft replacement ligament to replace a damaged anterior cruciate or other human ligament includes a ligament of suitable size and strength that has been harvested from a donor animal with a bone piece at least one end to preserve intact a substantial portion of a first natural ligament-to-bone attachment structure of the donor animal. Once harvested, it may be tanned and otherwise processed with glutaraldehyde solution. Installation includes pinning and otherwise attaching the bone piece at the natural attachment site of the patient to more closely replicate the natural ligament-to-bone attachment structure being replaced. The replacement ligament may be harvested with a bone piece at each end for this purpose, with each of the bone pieces then being attached at a natural attachment site of each of two bones of the patient.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: November 26, 1991
    Assignee: Baxter International Inc.
    Inventors: Todd D. Campbell, Michael A. Zozaya
  • Patent number: 5061277
    Abstract: A support for a natural heart valve is disclosed. The support is generally ring shaped and has a size and shape to fit against the natural heart valve annulus. First length of the support is flexible, and a second length of the support is less flexible than the first length of the support. Accordingly, when the support is implanted, the support can shape the heart valve annulus and the first length of the support allows contraction of the heart valve annulus therealong.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: October 29, 1991
    Assignee: Baxter International Inc.
    Inventors: Alain Carpentier, Ernest Lane
  • Patent number: 5061276
    Abstract: A vascular graft having a composite structure prepared by wrapping about the external surface of a tube having one or more layers of polytetrafluoroethylene or a polytetrafluoroethylene-elastomeric polymer blend, either alone or in combination, an elastic fiber, while maintaining the fiber under tension. The elastic fibers can be wound about the entire length of the tube while being maintained under the same of different degrees of tension. Furthermore, the elastic fibers may be wound about the tube under a higher degree of tension along locations adjacent the opposite ends the tubing.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: October 29, 1991
    Assignee: Baxter International Inc.
    Inventors: Roger Tu, Edwin Wang
  • Patent number: 5053031
    Abstract: An infusion system includes an implantable housing having a storage reservoir that is dimensioned and arranged to contain a supply of a medication and a holding reservoir that is dimensioned and arranged to receive a dosage of the medication from the storage reservoir. A pump assembly is included for enabling a patient to cause a dosage of the medication to be transferred from the storage reservoir to the holding reservoir, and pressurizing components maintain the dosage under pressure within the holding reservoir in order to cause the dosage to discharge through an output port to the infusion location. One embodiment accomplishes this with an elongated bladder of elastomeric material in fluid communication with the storage reservoir and the output port. The bladder inflates as it fills with the dosage to maintain the dosage under pressure, and a capillary element disposed intermediate the bladder and the output port restricts the rate of discharge.
    Type: Grant
    Filed: March 21, 1989
    Date of Patent: October 1, 1991
    Assignee: Baxter International Inc.
    Inventor: Alexander S. Borsanyi