Patents Represented by Attorney Michael G. Penn

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  • Pharmaceutical formulations
    Patent number: 8314063
    Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: November 20, 2012
    Assignee: Amgen Inc.
    Inventors: Tiansheng Li, Christopher J. Sloey
  • Host cells comprising alpha 1,2 mannosidase and culture methods thereof
    Patent number: 8247210
    Abstract: Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: August 21, 2012
    Assignee: Amgen Inc.
    Inventor: Christopher K. Crowell
  • Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
    Patent number: 8221749
    Abstract: Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: July 17, 2012
    Assignee: Amgen Inc.
    Inventors: Thomas C. Boone, Jonathan D. Oliner
  • Antibody categorization based on binding characteristics
    Patent number: 8206936
    Abstract: Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: June 26, 2012
    Assignee: Amgen Inc.
    Inventors: Wynn L. Walker, Michael L. Gallo, Xiao-Chi Jia, Keith Joho, Jaspal Singh Kang
  • Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
    Patent number: 8030025
    Abstract: Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 4, 2011
    Assignee: Amgen Inc.
    Inventors: Thomas C. Boone, Jonathan D. Oliner
  • Production of glycoproteins using manganese
    Patent number: 7972810
    Abstract: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: July 5, 2011
    Assignee: Amgen Inc.
    Inventors: Christopher K. Crowell, Gustavo E. Grampp
  • Response element regions
    Patent number: 7892733
    Abstract: Response element regions, DNA constructs comprising response element regions, host cells comprising response element regions, and methods of using response element regions are provided.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: February 22, 2011
    Assignee: Amgen Inc.
    Inventors: Christiaan J. M. Saris, Shamin Summer, Sharon X. Mu, Jill A. Crouse
  • Host cells comprising alpha 1,2 mannosidase and culture methods thereof
    Patent number: 7888101
    Abstract: Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: February 15, 2011
    Assignee: Amgen Inc.
    Inventor: Christopher K. Crowell
  • Pharmaceutical formulations
    Patent number: 7790679
    Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: September 7, 2010
    Assignee: Amgen Inc.
    Inventors: Tiansheng Li, Christopher J. Sloey
  • Antibody categorization based on binding characteristics
    Patent number: 7771951
    Abstract: Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: August 10, 2010
    Assignee: Amgen Fremont Inc.
    Inventors: Wynn L. Walker, Michael L. Gallo, Xiao-Chi Jia, Keith Joho, Jaspal Singh Kang