Patents Represented by Attorney Michael Haukaas

Find this attorney in the Justia Lawyer Directory

  • Phosphoramidate derivatives of FAU
    Patent number: 7888330
    Abstract: The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: February 15, 2011
    Assignee: Wayne State University
    Inventors: Anthony F. Shields, Jiri Zemlicka, Sridhar Nimmagadda