Abstract: Method and apparatus for detecting or analyzing chemical reactions, such as an enzyme reaction, and other events in which electron translation is accompanied by photon emission utilizing a magnetometer probe to detect a change in electromagnetic field strength as a characterization of the event or of a substance. The event may be of unknown cause and a recorded time course of the change in electromagnetic field strength may be compared with known time course of known events to determine the cause of the unknown cause event. Similarly, a chemical substance may be detected and its identity determined.
Abstract: Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an adjuvanting effect on an antigen which is greater than the adjuvanting effect attainable by one of the adjuvants alone. An antigen is covalently bonded to a glycolipid analog to provide a discrete molecule which exhibits an enhanced adjuvanting effect on the antigen which is greater than the adjuvanting effect attainable in the absence of such covalent bonding.
Type:
Grant
Filed:
June 16, 1994
Date of Patent:
July 20, 2004
Assignee:
Aventis Pasteur Limited
Inventors:
Ali Kandil, Olive A. James, Michel H. Klein, Pele Chong
Abstract: A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a high level of protection to be achieved.
Type:
Grant
Filed:
December 3, 1999
Date of Patent:
January 13, 2004
Assignees:
University of Manitoba, Aventis Pasteur Limited
Abstract: Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
Type:
Grant
Filed:
May 17, 1996
Date of Patent:
March 26, 2002
Assignee:
Aventis Pasteur Limited
Inventors:
Sheena M. Loosmore, Robin E. Harkness, Anthony B. Schryvers, Pele Chong, Scott Gray-Owen, Yan-Ping Yang, Andrew D. Murdin, Michel H. Klein
Abstract: Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an adjuvanting effect on an antigen which is greater than the adjuvanting effect attainable by one of the adjuvants alone. An antigen is covalently bonded to a glycolipid analog to provide a discrete molecule which exhibits an enhanced adjuvanting effect on the antigen which is greater than the adjuvanting effect attainable in the absence of such covalent bonding.
Type:
Grant
Filed:
February 26, 1997
Date of Patent:
September 18, 2001
Assignee:
Aventis Pasteur Limited
Inventors:
Ali Kandil, Olive A. James, Pele Chong, Michel H. Klein
Abstract: An infinitely-variable bi-directional power transmission utilizes the differential in power input applied to members of a planetary gear set to control the speed and direction of rotation of a power output shaft also connected to the planetary gear set.