Abstract: A method and system for pre-processing a radiation image containing a clinical region of interest and a non-clinical region. The method includes forming a border proximate the clinical region and performing image filtering to filter the clinical region and the border. The non-clinical region may be collimated, and at least a portion of the collimated region may be replaced with values based on pixel values within the region of interest. The system includes obtaining a radiation image having clinical and non-clinical regions, apparatus identifying the non-clinical region, a multi-resolution pre-processing subsystem removing the non clinical region to form an intermediate image and then adding a border to the intermediate image, and a multi-resolution imaging subsystem performing multi-resolution processing of the clinical region and border. Assigned border pixels values may be based on, equal to, or mirror associated or adjacent clinical region pixel values.