Abstract: A compound of the structure is described. This compound and its use for preparing medicines useful in the treatment of neurodegenerative disorders is described.

Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is O.

Abstract: The present invention relates to medical uses of 39-desmethoxyrapamycin.

Abstract: The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A method is provided for use of a concrete composition and an associated apparatus. The method provides for mixing of the concrete material, accelerant powder and, optionally, an associated substance to enable the controlled hardening of the concrete material in a monolithic structure. The apparatus can dispose a slip-plane film to facilitate a relatively continuous process.

Abstract: According to the invention, a method for identifying and determining die position of a metallurgical vessel for measuring its fireproof lining using electromagnetic radiation, an operator is defined in relation to a two or three dimensional structure with a known shape and size. Distance values and corresponding measuring angles are determined in the area of the structure and measured distance value and corresponding measuring angles are used to scale the operator. The dimension and resolution of the operator in the pixel coordinates system and the anticipated values of the operator are adapted to the measured polar coordinates. A result value is then formed from the differences between the anticipated values of the operator and the measured values and the location of the structure that is sought is determined from the position of the minimum result value.

Abstract: An apparatus for the gunning of a material is provided having a nozzle with an inner passage having an inlet end into which a wetted material is to be introduced and an outlet end from which the material is to be sprayed. An outer passage is disposed around the inner passage and in fluid communication therewith and has an inlet end for introducing a gas to be passed through the outer passage and impinged on the wetted material passing through the inner passage. Also provided is an apparatus for the gunning of a material having a material delivery hose for providing a material. A water inlet in fluid communication with the material delivery hose provides water to wet the material and a nozzle outputs the wetted material. A mixing chamber is disposed intermediate and in fluid communication with the material delivery hose and the nozzle and has at least one inlet for introducing a mixing gas.

Abstract: The process of the present invention is directed to a method for making zinc or zinc-aluminum alloy additions to galvanizing baths. The process involves addition of a wire of zinc or zinc-aluminum alloy introduced directly into a molten galvanizing bath to more rapidly achieve a desired zinc or zinc-aluminum chemistry thereby reducing the time required to make the bath addition.

Abstract: Novel polymers are provided having phosphonated and sulphonated substituent groups such that the polymer is multifunctional in its use. Optional amide substituents are used to reduce electrostatic charge density or for hydrogen bonding. An advantage of the polymer is the flexibility of using it for multiple purposes. A particular application is for bonding paper fillers and paper fiber together.

Abstract: A method of improving the brightness of calcium carbonate filled paper. The filled paper is dried and then bleached with an aqueous solution of a bleaching agent. The process may be used on all grades of paper that contain filler and is particularly useful in the bleaching of low brightness grade papers that are produced from mechanical pulp that contain calcium carbonate.

Abstract: The present invention relates to a product, a process for its preparation and the use of such in plastic film production. More specifically, the present invention relates to an antiblock talc, a process for the preparation of such and its use as an additive in the production of polyolefin film. Polyolefin films produced according to the process of the present invention are useful in a broad range of packaging and film covering applications.

Abstract: A process is disclosed in which coarse silica, calcium oxides and magnesium oxides are treated in a ball mill together with grinding aids and cold-strength binders. This material is then agglomerated with water to produce a product that reacts at elevated temperatures, e.g. in a fluidized bed reactor, to produce synthetic silicates.