Abstract: This hand-held pressurized applicator is very effective to apply medicants to the perio pocket area of the tooth-gum margin. This pressurized applicator can be held and used in any orientation. The medicant is applied at a pressure of greater than about 20 psi, and preferably a pressure of greater than about 30 psi. In one embodiment, there is used a tip that fits into the perio pocket of teeth, and in a second embodiment there is used a toothbrush with the medicant flowing from between the bristles of the toothbrush or through hollow bristles.