Abstract: The invention relates to the design, construction and use of eukaryotic cell lines useful in the identification of inhibitors of &bgr;-amyloid processing. More specifically, the invention relates to in vitro assays capable of identifying or quantifying a 4.2 kDa &bgr;-amyloid protein. The present invention also provides for DNA and protein molecules for the design, construction and use of eukaryotic cell lines useful in the identification of inhibitors of &bgr;-amyloid processing.
Type:
Grant
Filed:
February 20, 1998
Date of Patent:
December 30, 2003
Assignees:
Aventis Pharmaceuticals Inc., Scios Nova, Inc.
Inventors:
Rebecca Pruss, John Huggins, Guy Rautmann, Barbara Cordell, Jan Marian Scardina, Ronald P. Mischak