Patents Represented by Attorney Michael J. Schmelzer

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  • Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
    Patent number: 6861524
    Abstract: The present invention is directed to acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines of the formula where Z is selected from the group consisting of —S(O)2—, and —C(O)—.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: March 1, 2005
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: David Borcherding, Jennifer A. Dumont, Norton P. Peet, Paul S. Wright
  • Screening methods for altering circadian rhythms and for human casein kinase I &dgr; and/or &egr; phosphorylation of human clock proteins, period 1, -2 and -3
    Patent number: 6555328
    Abstract: The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI &dgr; and &egr; phosphorylation of a human Period protein. The present invention is also directed to a method for determing the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: April 29, 2003
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: George A. Keesler, Cesare Mondadori, Zhengbin Yao, Fernando Camacho