Patents Represented by Attorney, Agent or Law Firm Michael K. Kirschner
  • ACPL polypeptides
    Patent number: 6693171
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: February 17, 2004
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • ACPL antibodies
    Patent number: 6692740
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: February 17, 2004
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • DNA encoding ACPL
    Patent number: 6664077
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: December 16, 2003
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Nucleic acids encoding IKR-2, a protein kinase related to the I kappa B kinases
    Patent number: 6605456
    Abstract: The invention is directed to purified and isolated kappa B kinase-related kinases 1 and 2 (IKR-1 and IKR-2) polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: August 12, 2003
    Assignee: Immunex Corporation
    Inventors: Timothy A. Bird, G. Duke Virca
  • Antibodies that bind the cytokine designated LERK-5
    Patent number: 6596852
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: July 22, 2003
    Assignee: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy
  • TNF-.alpha. converting enzyme
    Patent number: 6013466
    Abstract: A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: January 11, 2000
    Assignee: Immunex Corporation
    Inventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti