Abstract: One or more cardiovascular parameters is estimated as a function of the arterial pressure waveform, in particular, using at least one statistical moment of a discrete representation pressure waveform having an order greater than one. Arterial compliance, the exponential pressure decay constant, vascular resistance, cardiac output, and stroke volume are examples of cardiovascular parameters that can be estimated using various aspects of the invention. In one embodiment of the invention, not only are the first four moments (mean, standard deviation, skewness, and kurtosis) of the pressure waveform used to estimate the cardiovascular parameter(s) of interest, but also heart rate, statistical moments of a set of pressure-weighted time values, and certain anthropometric patient measurements such as age, sex, body surface area, etc.

Abstract: A connector assembly couples signal lines for an optical catheter by providing a guided releasable latching mechanism that ensures optimal alignment with only a single vertical dimension under control. A receptacle carrying a first signal line defines a channel for receiving a plug carrying a second signal line. A spring-loaded pawl on the receptacle locks to a retaining bracket on the plug when the plug slides into the channel, imparting a retaining force on the plug, the force having a first component normal to channel and a second component parallel to the channel to maintain the first and second signal lines in optimal alignment. The retaining bracket may include a sloped edge to allow for easy release of the pawl in the presence of a release force. The release force may be set to allow disconnection of the assembly without affecting catheter installation or causing patient discomfort.

Abstract: Cardiac stroke volume (SV) of a subject is estimated as a function of a value derived from a measured arterial pressure waveform. The value may be the standard deviation, or a function of the difference between maximum and minimum pressure values, or a function of either the maximum value of the first time derivative or the absolute value of the minimum of the first time derivative of the pressure waveform, or both, or a function of the magnitude of one or more spectral components of the pressure waveform at a frequency corresponding to the heart rate. Cardiac output is then estimated as the product of the subject's heart rate and SV, scaled by a calibration constant. Arterial pressure may be measured invasively or non-invasively.

Abstract: An apparatus for the measurement of at least one analyte in the blood of a patient, which includes a light source generating broadband light and a light-transmission arrangement having a plurality of transmitting fibers is positioned for simultaneously transmitting multiple wavelengths of the broadband light from the light source to the blood of the patient. The measurement apparatus further includes an optical fiber arrangement having a plurality of light detector fibers for leading multi-wavelength light, in spectrally unseparated form, transmitted through, or reflected from, the blood and a light detection arrangement for receiving the multi-wavelength light in its spectrally unseparated form from the optical fiber arrangement, for spectrally decomposing the received light, and for determining amplitudes of selected wavelengths of the decomposed light.

Abstract: The present invention provides a retractor for providing surgical access through a passage in tissue, together with methods for its use and deployment. The retractor comprises an anchoring frame having an upper surface, a lower surface, and an opening therethrough which defines an axial axis. A flexible tensioning member is attached to the frame, and is extendable from the frame out of the body through the passage when the frame is positioned through the passage and into a body cavity. This tensioning member is selectively tensionable to spread the tissue radially outwardly from the axial axis. Hence, it is the tension imposed on the flexible liner which effects retraction of the tissue, rather than relying on the structural integrity of an artificial lumen.

Abstract: A closed blood sampling system within a pressure monitoring line having a control valve that enables a clearance reservoir to be isolated from the pressure column when no samples are being taken. The valve is a stopcock-like device that includes a rotating valve member and attached control handle with clear visible and tactile indicators for the mode of operation. The rotating valve member has a number of internal and circumferential channels for connecting or disconnecting select ports in the core of the valve. By isolating the clearance reservoir, the quality of the pressure signal is improved such that the sampling line can be lengthened for greater convenience in the intensive care or operating room. The valve may also incorporate a blunt cannula sampling site therewithin.

Abstract: Ablation instruments and techniques are disclosed for accessing portions of the heart wall via the coronary sinus. While shielding the major portion of the sinus and/or the circumflex coronary artery from ablative energy, the present invention provides access to the heart wall to treat atrial fibrillation. In particular, the present invention provides instruments and methods for forming transmural lesions in the left atrium, such as the so-called “left isthmus block,” from within the coronary sinus.

Abstract: To manufacture a multi-core press-coated molded product efficiently and in a single step from molding materials, namely, powder or granular particles, a punch has been devised that is characterized in that the punch, consists of a center punch whose tip portion is split into two or more parts, and an outer punch enclosing the outer perimeter of the center punch, and whose tip portion fills the gap at the tip portion of the center punch, with both the center and outer punches being slidable and manipulatable for compression operation the method of manufacturing a multi-core press-coated molded product using the punch of the invention as compression molding means for at least the upper punch and preferably for both the upper and lower punches, and a rotary compression molding machine therefore is also discribed.

Abstract: A container assembly heats or cools a product inside an inner container. An outer jacket at least partially surrounds the inner container, with a first internal volume and a second internal volume in the space between the outer jacket and the inner container. A first temperature-change reagent is contained inside the first internal volume, and a second temperature-change reagent is held in the second internal volume, with a reagent separator between the two. Several penetrators are disposed to penetrate the reagent separator to produce openings through the separator and through which the two reagents can mix. Steel wool inside the first internal volume acts as a steam condenser. The outer jacket includes a jacket top ring secured around an upper surface of a standard can, a jacket body secured to the jacket top, and a flexible jacket bottom that carries several spikes molded onto the jacket bottom.