Abstract: The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.
Type:
Grant
Filed:
October 13, 1998
Date of Patent:
December 25, 2001
Assignee:
Curis, Inc.
Inventors:
Thangavel Kuberasampath, Charles M. Cohen, Herrmann Oppermann, Engin Ozkaynak, David C. Rueger, John E. Smart, Roy H. L. Pang
Abstract: Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptor; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
Type:
Grant
Filed:
June 2, 1995
Date of Patent:
July 25, 2000
Assignee:
Creative Biomolecules, Inc.
Inventors:
Donald F. Jin, Hermann Oppermann, Thangavel Kuberasampath, John E. Smart