Patents Represented by Attorney Michael T. Murphy

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  • Water based aerosol coatings
    Patent number: 4518734
    Abstract: Water based aerosol coatings which comprise water reducible resin, dimethylether, water and water soluble solvent are described. The improved water reducible aerosol coatings can be cleaned up with water, have high gloss, are non-flammable and contain no aromatic hydrocarbons such as toluene or xylene.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: May 21, 1985
    Assignee: Rust-Oleum Corporation
    Inventors: Bruce R. Brouillette, Martha J. Shafer
  • Method of producing pigmented silicate coatings
    Patent number: 4294619
    Abstract: Use of ethyl hydroxy ethyl cellulose to aid in dispersion and suspension of pigment and control of application rheology in inorganic zinc-rich primers made with partially hydrolyzed ethyl silicate resins is described.
    Type: Grant
    Filed: April 1, 1980
    Date of Patent: October 13, 1981
    Assignee: Rust-Oleum Corporation
    Inventors: Donald C. Dulaney, John A. Bowman
  • Method of producing silicate binders and coatings
    Patent number: 4290811
    Abstract: An improved method of preparing hydrolyzed alkyl silicate binders useful in manufacturing protective coatings, i.e., zinc-rich coatings, is described wherein the hydrolysis is catalyzed in the presence of a strong acid form ion exchange resin instead of a conventional acid catalyst.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: September 22, 1981
    Assignee: Rust-Oleum Corporation
    Inventors: Kenneth H. Brown, Kenneth M. Wolma
  • Anti-diarrheal 2-substituted quinuclidines
    Patent number: 4203990
    Abstract: The present invention provides 2-substituted quinuclidines of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is phenyl, halogen-substituted phenyl, lower alkyl-substituted phenyl, pyridyl or 5-methyl-1,3,4-oxadiazol-2-yl.These quinuclidine compounds are useful as anti-diarrheal agents.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: May 20, 1980
    Assignee: G. D. Searle & Co.
    Inventor: Chung H. Yen
  • Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
    Patent number: 4203989
    Abstract: The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula ##STR2## wherein R.sub.1 and R.sub.2 are each H or a C.sub.1 -C.sub.5 alkyl, and R.sub.3 is H or an acyl of the formula ##STR3## wherein R.sub.4 is H or a C.sub.1 -C.sub.4 alkyl. These alkanols are useful as antidiarrheal agents.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: May 20, 1980
    Assignee: G. D. Searle & Co.
    Inventors: Chung H. Yen, James R. Deason
  • 1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds
    Patent number: 4194045
    Abstract: This invention encompasses novel 1-(3,3-diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds. These compounds are useful anti-diarrheal agents which possess little or no analgesic activity.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: March 18, 1980
    Assignee: G. D. Searle & Co.
    Inventor: Gilbert W. Adelstein
  • 1-(Substituted amino)alkanoyl-2-(dibenzoxapine-10-carbonyl)hydrazines and derivatives thereof
    Patent number: 4170593
    Abstract: The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.
    Type: Grant
    Filed: August 25, 1978
    Date of Patent: October 9, 1979
    Assignee: G. D. Searle & Co.
    Inventor: Richard A. Mueller
  • Poly-5-hydroxycytidylic acid copolymers
    Patent number: 4151350
    Abstract: The invention relates to copolymers of 5-hydroxycytidylic acid and at least one other polynucleotide selected from cytidylic acid and monomers derived therefrom by bromination. The polymers of the invention are prepared by the bromination of polycytidylic acid and subsequent hydrolysis of the product. The copolymers of the invention demonstrate antiviral properties in vivo.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: April 24, 1979
    Assignee: G. D. Searle & Co.
    Inventors: Nowell Stebbing, Michael A. Eaton
  • Intermediates for prostaglandin synthesis
    Patent number: 4151187
    Abstract: Compounds of the formula ##STR1## wherein R is phenyl cyclohexyl or lower alkyl containing 1-6 carbon atoms; R" is hydrogen or methyl; R'" is alkenyl or alkynyl having 3-5 carbon atoms; R' is hydrogen, tetrahydrofuran-2-yl tetrahydropyran-2-yl or trialkylsilyl wherein the alkyl contains 1-4 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin like molecules which are active anti-secretory agents.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: April 24, 1979
    Assignee: G. D. Searle & Co.
    Inventors: Paul W. Collins, Raphael Pappo
  • Method for cleaving the peptide-resin bond in solid phase peptide synthesis by hydrogenolysis
    Patent number: 4113713
    Abstract: An improved process for cleaving peptides bound to a polymer by way of a benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: September 12, 1978
    Assignee: G. D. Searle & Co.
    Inventors: James M. Schlatter, Owen Goodmonson
  • 3-Alkoxy-D-homo-C-nor-13.alpha., 14.alpha.-gona-1,3,5,(10),6,8-pentaen-17-one and derivatives thereof
    Patent number: 4064177
    Abstract: The present invention relates to 3-alkoxy-D-homo-C-nor-13.alpha.,14.alpha.-gona-1,3,5(10),6,8-pentaen-17-on e and certain derivatives thereof. The compounds of this invention display valuable pharmacological activities, such as antispasmodic utility.
    Type: Grant
    Filed: April 11, 1977
    Date of Patent: December 20, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Richard M. Weier
  • 3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof
    Patent number: 4056562
    Abstract: 3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof, conveniently obtained by processes utilizing 2-formyl-3-hydroxy-5-oxycyclopent-1-eneheptanoic acids as the starting materials, display valuable pharmacological properties, e.g. antifertility, bronchodilating, anti-secretory, smooth muscle stimulatory, and blood platelet aggregation-inhibiting.
    Type: Grant
    Filed: July 19, 1976
    Date of Patent: November 1, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Richard A. Mueller
  • 3,5-Bisoxygenated 2-(.omega.-halo-3-oxo-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof
    Patent number: 4041050
    Abstract: The compounds of the present invention are useful intermediates for the manufacture of 3,5-dihydroxy-2-(.omega.-halo-3-hydroxy-1-alkenyl)cyclopentane-1-heptanoic acids and derivatives thereof. The latter compounds display valuable pharmacological properties, e.g. anti-fertility, bronchodilating, anti-secretory, smooth muscle stimulator and blood platelet aggregation-inhibiting.
    Type: Grant
    Filed: September 20, 1976
    Date of Patent: August 9, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Richard A. Mueller
  • 2 AND 3-SUBSTITUTED ENKEPHALINS
    Patent number: 4028319
    Abstract: Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: June 7, 1977
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Jr., James M. Schlatter, Richard A. Mikulec, Judith A. Reuter, Robert H. Mazur
  • 3-Amino-N-substituted succinamic acids and intermediates thereto
    Patent number: 4011260
    Abstract: The above-captioned compounds, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and exhibit also pharmacological, e.g. anti-inflammatory, properties.
    Type: Grant
    Filed: February 14, 1974
    Date of Patent: March 8, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
  • Deuterated prostaglandin analogs
    Patent number: 4002663
    Abstract: Deuterated analogs of prostaglandins have been prepared and found to display increased activity as antifertility, bronchodilator and/or bronchoconstrictor agents compared to the natural prostaglandins. The analogs are conveniently prepared by reduction of the 15-keto group and/or the 9-keto group with a deuterated reducing agent.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: January 11, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Masateru Miyano
  • 3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof
    Patent number: 3997588
    Abstract: 3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof, conveniently obtained by processes utilizing 2-formyl-3-hydroxy-5-oxycyclopent-1-eneheptanoic acids as the starting materials, display valuable pharmacological properties, e.g. anti-fertility, bronchodilating, anti-secretory, smooth muscle stimulatory, and blood platelet aggregation-inhibiting.
    Type: Grant
    Filed: May 15, 1975
    Date of Patent: December 14, 1976
    Assignee: G. D. Searle & Co.
    Inventor: Richard A. Mueller
  • N-Substituted aspartyl peptide amides
    Patent number: RE29324
    Abstract: Peptides containing the residues of methionine and aspartic acid are prepared by standard coupling techniques and display valuable pharmacological, e.g. gastrin-inhibitory, properties.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: July 26, 1977
    Assignee: G. D. Searle & Co.
    Inventors: David A. Jones, Robert H. Mazur