Patents Represented by Attorney, Agent or Law Firm Micheal D. Alexander - Justia Patents Search

Patents Represented by Attorney, Agent or Law Firm Micheal D. Alexander

Method for preparing (2s)-1-(2r3s)-5-chloro-3-(2-chlorophenyl) -1-(3,4-dimethoxy benzene-sulphonyl) 3-hydroxy-2,3-dihydro-1h-indole-2-carbonyl pyrrolidine-2-carboxamide

Patent number: 6355809

Abstract: An improved process for preparing (2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulphonyl)-3-hydroxy-2,3 -dihydro-1H-indole-2-carbonyl]pyrrolidine-2-carboxamide by cyclization of (2S)-1-{[[4-chloro-2-(2-chlorobenzoyl)phenyl]-(3,4-dimethoxybenzenesulphonyl)amino]acetyl}pyrrolidine-2-carboxamide in the presence of an alkali metal hydroxide in a mixture of polyethylene glycol and water.

Type: Grant

Filed: May 14, 2001

Date of Patent: March 12, 2002

Assignee: Sanofi-Synthelabo

Inventors: Dominique Chantreux, Philippe Mercey