Patents Represented by Attorney, Agent or Law Firm Micheline Gravelle
  • Patent number: 6287564
    Abstract: The invention relates to a method and use of a method of identifying high immune response animals under stress. The animals are identified by a ranking procedure that classifies the animal's immune response to an antigen over a period of time that spans the stress.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: September 11, 2001
    Inventors: Lauraine Wagter-Lesperance, Bonnie Mallard
  • Patent number: 6288304
    Abstract: The present invention provides a method of preparing somatotropins in plants and transgenic plant seeds containing somatotropins. The method provides an economical way to produce somatotropins.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: September 11, 2001
    Assignee: SemBioSys Genetics Inc.
    Inventors: Maurice M. Moloney, Hamid R. Habibi
  • Patent number: 6284375
    Abstract: A novel lipid vesicle system is described. This system consists of a lipid shell that is anchored on the surface of a polymer matrix. The system has potential applications in drug delivery, drug targeting, protein separation, enzyme immobilization and blood cell substitution.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: September 4, 2001
    Inventors: Tuo Jin, Peter Pennefather, Ping I. Lee
  • Patent number: 6274311
    Abstract: An isolated nucleic acid molecule is provided which contains a sequence which encodes a protein which mediates the uptake of L-malate, succinate, and malonate, and expression vectors and host cells containing the nucleic acid molecules. The nucleic acid molecules are used to transform cells for use in mediating malate, succinic acid or malonate uptake in particular malate uptake during the fermentation of wines.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: August 14, 2001
    Assignees: University of Guelph, University of Stellenbosch
    Inventors: Jandre Grobler, Aldis Krizus, Chauanpit Osothsilp-Deeknamakul, Isak S. Pretorius, Hendrick J. Jansen Van Vuuren, Ronald E. Subden
  • Patent number: 6271344
    Abstract: Novel hyaluronan-binding peptides are provided. The peptides are useful in preventing and treating disorders associated with altered tissue levels of hyaluronan or RHAMM, including cancer, inflammatory and autoimmune disorders and fibrotic disorders associated with tissue trauma.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: August 7, 2001
    Assignee: Cangene Corporation
    Inventor: Eva A. Turley
  • Patent number: 6248716
    Abstract: A peptide of the formula I X-Tyr-Y-Phe-Z-A  I wherein X is hydrogen, arginine, D-arginine, ornithine, D-ornithine, lysine, D-lysine, homoarginine, D-homoarginine, citrulline, D-citrulline; Tyr is tyrosine; Y is D-alanine, D-valine, D-leucine, D-isoleucine, D-phenylalanine, D-asparagine, D-tryptophan, D-proline, D-serine, D-threonine, D-tyrosine, D-hydroxyproline, D-cysteine, D-cysteyl-cysteine, D-methionine, D-lysine, D-homoarginine, D-arginine, D-histidine, D-aspartic acid, D-glutamic acid, D-&bgr;-alanine, or D-ornithine; Phe is phenylalanine; Z is alanine, D-alanine, valine, D-valine, leucine, D-leucine, isoleucine, D-isoleucine, phenylalanine, D-phenylalanine, asparagine, D-asparagine, glycine, glutamine, D-glutamine, tryptophan, D-tryptophan, proline, D-proline, serine, D-serine, threonine, D-threonine, tyrosine, D-tyrosine, hydroxyproline, D-hydroxyproline, cysteine, D-cysteine, cysteyl-cysteine, cysteine-D-cysteine, D-cysteyl-cysteine, D-cysteine-D-cysteine, methionine, D-methionine, lysin
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: June 19, 2001
    Assignee: Immunotech Developments Inc.
    Inventors: Vladislav I. Deigin, Elena P. Yarova
  • Patent number: 6245516
    Abstract: Nucleic acid probes and a method for their use in detecting and identifying Campylobacter, Helicobacter, and Arcobacter spp. bacterial pathogens are described. A method for prepg. specific nucleic acid probes for the detection of identification of any other bacterial pathogens is also provided.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: June 12, 2001
    Inventors: Shahnaz Tahihra Al Rashid, Voon Loong Chan
  • Patent number: 6238903
    Abstract: Novel SH2-containing inositol-phosphatase which has a src homology 2 (SH2) domain and exhibits phosphoIns-5-ptase activity, and nucleic acid molecules encoding the novel protein are disclosed. The invention also relates to methods for identifying substances which affect the binding of the protein to Shc and/or its phosphoIns-5-ptase activity and methods for screening for agonists or antagonists of the binding of the protein and Shc.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: May 29, 2001
    Inventor: Gerald Krystal
  • Patent number: 6210742
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: April 3, 2001
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Soheil Mahmoud, Maurice M. Moloney
  • Patent number: 6194207
    Abstract: The invention is directed to methods for the production of selected populations of lymphocytes. Lymphocytes produced can be isolated and purified using well known and established procedures to provide a consistent lymphocyte source which one of ordinary skill in the art can modify to provide an appropriate type or an optimal level of a desired lymphocyte. The availability of such cell populations allows for not only for the complete reconstitution of the depleted, defective or missing lymphocyte population in a patient, but also provides the flexibility of having sufficient cells to permit multiple or cyclic treatments. These methods for expanding target cell populations are broadly applicable to the selective expansion of several types of lymphocytes and are demonstrated to maintain phenotype as well as antigen specificity.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: February 27, 2001
    Assignee: Hemosol Inc.
    Inventors: David N. Bell, Truman Wong
  • Patent number: 5650554
    Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oleosins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: July 22, 1997
    Assignee: SemBioSys Genetics Inc.
    Inventor: Maurice Moloney