Patents Represented by Law Firm Millen, White and Zelano
  • Patent number: 7427390
    Abstract: This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: September 23, 2008
    Assignee: Schering AG
    Inventors: Matthias Friebe, Peter Muschick, Andreas Huth
  • Patent number: 7427618
    Abstract: Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: September 23, 2008
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz, Christoph van Amsterdam
  • Patent number: 7425574
    Abstract: Novel benzofuranoxyethylamines of the formula (I), in which R1, R2, R3, R4, m and n have the meanings indicated in Patent Claim (1), which have a strong affinity to the 5 HT1A receptors and/or 5HT1D receptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics, antipsychotics, neuroleptics and/or antihypertonics.
    Type: Grant
    Filed: January 19, 2004
    Date of Patent: September 16, 2008
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Günter Hölzemann, Kai Schiemann, Henning Böttcher, Timo Heinrich, Christoph Seyfried, Joachim Leibrock, Chrisoph Van Amsterdam, Gerd Bartoszyk
  • Patent number: 7425355
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds which comprises at least one compound of the formula I in which R11, R12, and L1-6 have the meanings indicated in Claim 1, is described. Also described is the use thereof for an active-matrix display based on the ECB, PALC, FFS or IPS effect.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: September 16, 2008
    Assignee: Merck Patent GmbH
    Inventors: Melanie Klasen-Memmer, Matthias Bremer, Elvira Montenegro
  • Patent number: 7422728
    Abstract: A reactor intended to carry out partial oxidation reactions starting from liquid feedstocks that can go from GPL to gas oil for the purpose of producing synthesis gas is characterized by finely controlled hydrodynamics and a high degree of thermal integration, and comprises an elongated jacket along an axis of any orientation, means (12) for supplying a preheated gas that contains oxygen and optionally water vapor, means (9) for supplying a hydrocarbon feedstock, means (11) for evacuation of a hydrogen-rich effluent, a first internal chamber (5) inside of which is carried out an essentially isothermal partial oxidation reaction that is connected to means (9) for supplying the hydrocarbon feedstock and to means (12) for supplying preheated gas, gas turbulizing means that are suitable for creating a perfect mixing flow, means (8) for linking first chamber (5) to a second chamber (7) with a suitable volume for carrying out a piston flow, linking means (8) that comprise at least one orifice, and second chamber (7
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: September 9, 2008
    Assignee: Institut Francais du Petrole
    Inventors: Luc Nougier, Stéphane Bertholin, Willy Nastoll
  • Patent number: 7419705
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds, characterized in that it comprises one or more compounds of the formula I in which R1, L1 and L2 are as defined in claim 1, and to the use thereof for electro-optical purposes, in particular TN monitor applications.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: September 2, 2008
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Volker Reiffenrath, Izumi Saito
  • Patent number: 7419972
    Abstract: The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of estrogen-dependent diseases that can be influenced by the inhibition of 17?-hydroxy steroid dehydrogenase type 1.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: September 2, 2008
    Assignee: Schering AG
    Inventors: Alexander Hillisch, Olaf Peters, Christian Gege, Wilko Regenhardt, Andrea Rosinus, Jerzy Adamski, Gabriele Moeller, Walter Elger, Birgitt Schneider, Ulrich Bothe
  • Patent number: 7419931
    Abstract: A catalyst is described which comprises at least one zeolite with channels with openings defined by a ring having 10 oxygen atoms (10 MI), at least one zeolite with at least channels or side pockets with openings defined by a ring having 12 oxygen atoms (12 MR), at least one metal selected from the group constituted by group IIIA and VIIB metals and at least one porous mineral matrix. Said catalyst optionally also contains at least one metal selected from the group constituted by group IVA and VIB metals. The catalyst of the invention is used in a process for the transalkylation of alkylaromatic hydrocarbons such as toluene or benzene and alkylaromatics containing at least 9 carbon atoms.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: September 2, 2008
    Assignee: Institute Francais du Petrole
    Inventors: José Manuel Serra, Avelino Corma, Emmanuelle Guillon
  • Patent number: 7419706
    Abstract: The present invention relates to a liquid crystalline mixture comprising a) 1-25% by weight of at least one compound of the formula I b) 5-80% by weight of at least one compound of the formula II c) and optionally 1-20% by weight of at least one chiral compound with a HTP of ?20 ?m, wherein R11, A11, Z11, A12, Z12, L11, L12, L13, L14, Z13, A13, Z14, A14, X11, a, b, c, d, R12, A1, Z1, A2, Z2, A3, L1, L2, X12, m and n have the meanings given in claim 1 and their use in TFT, TN, IPS applications and expecially for devices utilizing electro-optical effects in an optically isotropic state.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: September 2, 2008
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Michael Heckmeier, Achim Goetz, Markus Czanta, John Patrick, Louise Diane Farrand, Cecile Schott, Elvira Montenegro, Peer Kirsch
  • Patent number: 7420073
    Abstract: A process that employs a heterogeneous catalyst comprising a zinc aluminate mixed oxide and having the following formula: ZnAl2O4, xZnO, yAl2O3 in which x and y each represent a number in the range 0 to 2, and in which the zinc aluminate is more particularly of the spinel type, makes it possible, by means of C1 to C5 monoalcohols, to: transesterify vegetable or animal oils having a natural free acidity, such as unrefined degummed rapeseed, soya, sunflower oils or exotic oils of the African oil, palm nut oil or coconut oil type, which are naturally rich in fatty acids; and simultaneously esterify their free acidity; so as to use phospholipid free and/or degummed unrefined acid oil with an acid number in the range 0.5 to 20, for example 1 to 15 and preferably 2 to 12, to produce esters, for example methyl esters, for use as fuels.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: September 2, 2008
    Assignee: Institut Francais du Petrole
    Inventors: Gérard Hillion, Dominique Le Pennec
  • Patent number: 7419538
    Abstract: Highly anti-corrosive thin-platelet like metal pigments having high corrosion resistance and good dispersibility characterized in that the inherent metallic luster of the thin-platelet like metal substrates is maintained without demanding the original surface smoothness are provided. The highly anti-corrosive thin-platelet like metal pigments comprising, on the surface of thin-platelet like metal substrates treated with phosphoric acid compounds and/or boric acid compounds, one or more coated layers containing one or more hydrated metal oxides of one or more metals selected from the group consisting of silicon, aluminum, zirconium, titanium and tin.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: September 2, 2008
    Assignee: Merck Patent GmbH
    Inventors: Bangyin Li, Nobuaki Nakamura, Katsuhisa Nitta
  • Patent number: 7417018
    Abstract: The invention relates to a method of cleaning a solid surface comprising the following stages: a) the solid surface is cleaned using a microemulsion-type cleaning composition; e) the cleaned surface is drained; f) the drained surface is rinsed with an organic solvent or a mixture of organic solvents with a low boiling point; and g) said surface which was rinsed with the organic solvent or the mixture of organic solvents used in c) is then dried.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: August 26, 2008
    Assignee: ATOFINA
    Inventors: Pascal Michaud, Jean-Claude Lheureux
  • Patent number: 7416866
    Abstract: A process for the overexpression of dehydrogenases, especially for the overexpression of ?1-dehydrogenases, in particular for the overexpression of 3-keto steroid-?1-dehydrogenases, as well as for the bacteria, plasmids and DNA sequences that can be used for the overexpression, is described.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: August 26, 2008
    Assignee: Schering AG
    Inventor: Tillmann Spelling
  • Patent number: 7417016
    Abstract: The present invention relates to a composition for the removal of so-called “sidewall residues” from metal surfaces, in particular from aluminium or aluminium-containing surfaces, in particular from aluminium or aluminium-containing surfaces, during the production of semiconductor elements.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: August 26, 2008
    Assignee: BASF SE
    Inventors: Raimund Mellies, Marc Boerner, Lucia Arnold, Andrea Barko, Rudolf Rhein
  • Patent number: 7417056
    Abstract: Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: August 26, 2008
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Heike Schaecke, Norbert Schmees, Werner Skuballa, Jan Huebner, Orlin Petrov, Matthias Schneider, Christian Dinter
  • Patent number: 7417157
    Abstract: Disclosed are hexahydrodibenzofuran compounds of formula I, the preparation thereof, the use thereof as components in liquid-crystalline media, and to electro-optical display elements which contain the liquid-crystalline media according to the invention.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: August 26, 2008
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Axel Jansen, Andreas Taugerbeck, Melanie Klasen-Memmer
  • Patent number: 7416894
    Abstract: The invention relates to water standards that are producible by grounding and mixing at least one component abounding in water and one water-free or low water component each. The inventive water standards are characterized by a good storage stability. They are suitable for the calibration or the inspection of devices to determine the water content after thermal release, especially for determining the water content according to Karl Fischer in combination with a Karl Fischer oven (Karl-Fischer oven technique).
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: August 26, 2008
    Assignee: Merck Patent GmbH
    Inventors: Silke Gruenke, Stefanie Bauer
  • Patent number: 7416688
    Abstract: Disclosed are transparent conductive pigments of flake-form substrates coated with a conductive layer, where the number-weighted mean particle area F50 of the transparent conductive pigments is greater than or equal to 150 ?m2, and processes for the production of the pigments, and the use thereof.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: August 26, 2008
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Gerhard Pfaff, Reinhold Rueger, Otto Stahlecker, Frank Ott
  • Patent number: 7417066
    Abstract: The invention relates to compounds of general Formula I, the production thereof, and the use thereof as a medicinal product.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: August 26, 2008
    Assignee: Schering AG
    Inventors: Bernd Buchmann, Martin Fritsch, Duy Nguyen, Bernd Menzenbach, Ulf Boemer
  • Patent number: 7414043
    Abstract: This invention describes the new 9?-substituted estratrienes of general formula I in which R3, R7, R7?, R13, R16 as well as R17 and R17? have the meanings that are indicated in the description and R9 means a straight-chain or branched-chain, optionally partially or completely halogenated alkenyl radical with 2 to 6 carbon atoms, an ethinyl or prop-1-inyl radical, as pharmaceutical active ingredients that exhibit in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo preferably a preferential action on the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The invention also describes the use of these compounds for treating estrogen-deficiency-induced diseases and conditions.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: August 19, 2008
    Assignee: Schering AG
    Inventors: Dirk Kosemund, Gerd Mueller, Alexander Hillisch, Karl-Heinrich Fritzemeier, Peter Muhn