Abstract: A process is described in which an unsaturated fat is reacted in a homometathesis reaction in the presence of at least one non-aqueous ionic liquid to produce both an olefinic fraction and a composition of monoalcohol diesters or diacids. Particular application to a mixture of esters of an oleic sunflower seed oil or an oleic rapeseed oil, the process producing both an olefinic fraction and a composition of monoalcohol diesters or diacids wherein, in general, more than half of its chains is constituted by unsaturated C18 chains.
Abstract: Novel compounds of the formula I in which R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
Abstract: The present invention relates to a process for the preparation of monohydroperfluoroalkanes, bis(perfluoroalkyl)phosphinates and perfluoroalkylphosphonates which comprises at least the treatment of at least one perfluoroalkylphosphorane with at least one base in a suitable reaction medium.
Type:
Grant
Filed:
March 17, 2003
Date of Patent:
December 5, 2006
Assignee:
Merck Patent Gesellschaft
Inventors:
Nikolai Ignatyev, Michael Weiden, Urs Welz-Biermann, Udo Heider, Peter Sartori, Andriy Kucheryna, Helge Willner
Abstract: The present invention is directed to a method of treating hepatitis B viral infections in mammals comprising the administration of .beta.-L-5-fluoro-2',3'-dideoxycytidine and pharmaceutically acceptable derivatives thereof.
Abstract: These compounds are denoted by the formula (I): ##STR1## in which R denotes a tert-butyl, tert-amyl or 2-ethylhexyl radical. To prepare them, methacrylic acid is reacted with a tetraalkoxytitanium Ti(OR).sub.4, where R=isopropyl or tert-butyl, to obtain a corresponding compound (I), or with Ti(OR) (OtAm).sub.3, where R=isopropyl or tert-butyl and tAm=tert-amyl, to obtain a compound (I) with R=tert-amyl, the compounds (I) with R=isopropyl or tert-butyl furthermore denoting intermediate synthesis products which can be reacted with tert-amyl alcohol or with 2-ethylhexanol, to obtain a compound (I) in which R denotes tert-amyl or 2-ethylhexyl respectively.
Type:
Grant
Filed:
November 4, 1998
Date of Patent:
December 7, 1999
Assignee:
Elf Atochem S.A.
Inventors:
Alain Riondel, Michel Camail, Andre Margaillan, Jean-Louis Vernet, Marie Humbert
Abstract: Process for the manufacture of .alpha.-fluoroacrylates of general formula: ##STR1## with R' alkyl, aryl or cycloalkyl, according to which source of formalin, consisting of paraformaldehyde is reacted with an .alpha.-fluorophosphonoacetate in aqueous medium in the presence of a salt of a weak inorganic acid.
Type:
Grant
Filed:
July 2, 1992
Date of Patent:
July 27, 1993
Assignee:
Elf Atochem S.A.
Inventors:
Claude Grison, Nathalie Boulliung, Philippe Coutrot