Abstract: An injection device adapted to the luer lock system and a syringe holder for making it is disclosed. The syringe holder for holding an inserted syringe, with a cap attached to the male luer at the tip, comprises a cylindrical barrel portion having an open distal end and an open proximal end, and a finger rest around the outer surface of the barrel portion at a position relatively closer to the proximal end, wherein a stopper means is provided at the inner surface of the barrel portion at the distal end thereof, the stopper means being designed to abut on the outer edge of the distal end of the syringe, and wherein a female-threaded sleeve extends forwardly from the distal end of the barrel portion, which is designed to surround the tip of the syringe and the cap, and wherein a proximal end cap is provided, at the proximal end of the barrel portion, which is designed to abut on the outer edge of the proximal end of the syringe, and has a bore to pass the piston rod through.
Abstract: The present invention describes a method of producing fatty acid alkyl esters and glycerin implementing, in a reaction section, a set of transesterification reactions between a vegetable or animal oil and an aliphatic monoalcohol, and using a heterogeneous solid catalyst, comprising: a) a stage of recontacting the effluent coming from the reaction section, and separated from the excess alcohol, with a glycerin phase, b) a stage of mixing said effluent with said glycerin phase, and c) a glycerin phase decantation stage. The supernatent ester phase obtained after decantation is then optionally sent to a coalescer, also allowing separation of the glycerin, then to a purification stage by adsorption on solids.
Abstract: The present invention relates to a liquid-crystalline medium having high twist, to the use thereof for electro-optical purposes, and to displays containing this medium.
Type:
Grant
Filed:
June 23, 2011
Date of Patent:
January 8, 2013
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Abstract: The invention relates to phosphors having a garnet structure of the formula I (Ya,Lub,Sec,Tbd,The,Irf,Sbg)3?x (Al5?yMgy/2Siy/2)O12:Cex (I), where a+b+c+d+e+f+g+h+i=1 x=0.005 to 0.1 and y=0 to 4.0, and to a process for the preparation of these phosphors and to the use as conversion phosphors for conversion of the blue or near-UV emission from an LED.
Type:
Grant
Filed:
September 2, 2009
Date of Patent:
January 8, 2013
Assignee:
Merck Patent GmbH
Inventors:
Holger Winkler, Thomas Juestel, Julian Plewa
Abstract: The present invention concerns a fluid distributor in a multistage column, each plate P of the column being divided into a certain number of panels Pa, and each panel Pa being equipped with a distributor of the invention, said distributor comprising: a) a solid jet breaker located substantially in the axis of the outlet opening of the collecting baffle of the panel Pa; b) an intermediate perforated plate extending laterally beyond the jet breaker, with a degree of opening in the range 10% to 40%; c) a distribution plate extending over the entire panel Pa, and with a degree of opening in the range 5% to 20%.
Abstract: A process for sequestrating carbon emitted into the atmosphere in the form of CO2 comprises: a) a step for concentrating CO2 in the liquid phase; b) a step for electro-reduction in an aprotic medium to a compound in which the carbon changes to oxidation number +3 in the form of oxalic acid or formic acid; c) if appropriate, a step for re-extracting oxalic or formic acid in the aqueous phase; and d) a step for mineralization by reaction with a compound of an element M, resulting in a stable compound in which the atomic ratio C/M is about 2/1.
Type:
Grant
Filed:
December 10, 2004
Date of Patent:
January 8, 2013
Assignee:
IFP Energies nouvelles
Inventors:
Hervé Toulhoat, François Ropital, Sébastien Duval
Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
Type:
Grant
Filed:
February 16, 2012
Date of Patent:
January 8, 2013
Assignee:
Merck Patent GmbH
Inventors:
Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
Abstract: The invention concerns a homogeneous bed of particles of a catalyst, said catalyst comprising at least one amorphous matrix, at least one noble metal, at least one additional metal M and at least one halogen, and in which, for a catalyst particle, CPt is the local concentration of noble metal Pt; CM is the local concentration of additional metal M; CX is the local concentration of halogen; said catalyst being in the form of a homogeneous bed of particles, in which across the diameter of the particle, at least 70% of the values CPt/CM or CPt/CX differ from the mean local ratio by at most 30%, and in which the mole ratio M/Pt in the catalyst is in the range 1.8 to 6.
Abstract: A cutter includes a male blade, a female blade, an advancement and retraction controller and a suction device. The male blade includes: a linear cutting portion linearly shaped with a predetermined thickness in a center part; a rounded cutting portion where a radius having a substantially arc shape in planar view is continuously formed from the linear cutting portion; and an end provided adjacent to the rounded cutting portion. The female blade has a fitting portion that is a hole conforming to the profile of the male blade in planar view and to which the male blade is fitted. On a lateral side of the female blade, an elongated hole for inserting a base film from one lateral side to the other lateral side is formed as an insertion portion.
Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
Type:
Grant
Filed:
April 11, 2008
Date of Patent:
January 1, 2013
Assignee:
Merck Eprova AG
Inventors:
Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Thomas Leighton Mindt, Viola Groehn
Abstract: In a fluid-transfer coupling device (5) that connects a plug (70) and a socket (10) to each other to communicate respective flow paths in the socket and the plug with each other, the plug includes, at least, an inner spacer (74) having an inner passage (78) formed to allow a passage of fluid, a plug collar (73) covering the outer circumferential surface of the inner spacer and a flange (75) formed on a proximal end of the plug to connect the plug to a conduit. The plug collar and the flange are made of metal. Consequently, even if the flow rate of the fluid is large, the plug can be firmly supported in the device. The inner spacer is made of a resinous material. In this connection, at least one portion of an outer circumferential portion of the plug may be formed of metal.
Abstract: The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malaria caused by plasmodia.
Abstract: Crystal forms of (6R)-L-erythro-tetrahydrobiopterin dihydrochloride, hydrates and solvates and processes for their preparation are provided. These crystal forms are either intermediates for the preparation of stable polymorphic form B or are suitable for solid formulations.
Type:
Grant
Filed:
May 10, 2010
Date of Patent:
January 1, 2013
Assignee:
Merck Eprova AG
Inventors:
Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter
Abstract: A speed synchronization system in an aluminum alloy slab continuous casting and rolling line having a twin-belt casting machine and skin pass rolling machine which suitably controls a belt speed of the twin-belt casting machine and roll speed of the skin pass rolling machine so as to obtain a sound aluminum alloy continuously cast and rolled slab and a production facility and method of production of an aluminum alloy continuously cast and rolled slab using the same.
Abstract: A compact device for mixing fluids in a downflow reactor comprising at least one substantially horizontal gathering device provided with a vertical gathering line intended to receive the fluids, at least one injection device arranged in the gathering line, an annular mixing chamber located downstream from the gathering means in the direction of circulation of the fluids, the mixing chamber comprising an inlet end directly connected to the gathering line and an outlet end for passage of the fluids, and a horizontal predistribution plate comprising at least one chimney, the plate being located downstream from the mixing chamber at a distance d2, in the direction of circulation of the fluids. The reactor is especially useful for exothermic reactions, e.g. hydrotreatment, hydrodesulfurization, hydrodenitrogenation, hydrocracking, hydrogenation and hydrodearomatization reactions.
Abstract: Disclosed are yellowing-stable, silver-white effect pigments having high whiteness based on synthetic mica flakes and to the use thereof in paints, lacquers, printing inks, plastics, button pastes, ceramic materials, glasses, for coloring seed, as dopant in laser markings of plastics and papers, as additive for laser welding of plastics, as additive for coloring in the foods and pharmaceuticals sectors and in cosmetic formulations, and for the preparation of pigment compositions and dry preparations.
Type:
Grant
Filed:
February 17, 2010
Date of Patent:
December 25, 2012
Assignee:
Merck Patent GmbH
Inventors:
Gerhard Pfaff, Johann Dietz, Sabine Schoen, Doreen Warthe
Abstract: Described are methods for providing prolonged physiologically acceptable steady state serum testosterone levels in a patient deficient in endogenous testosterone levels, methods for male contraception and methods for treating a disease or symptom associated with deficient endogenous levels of testosterone in a man, by intramuscularly administering testosterone esters in a vehicle.
Abstract: The present invention relates to the use of phosphinic acids and/or phosphonic acids and salts thereof for wetting fluorine compounds, in particular fluoropolymers, to the use in coating solutions comprising fluorine compounds, and to polymerisation processes in which fluorine compounds are used and/or formed.
Type:
Grant
Filed:
November 22, 2008
Date of Patent:
December 25, 2012
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Inventors:
Wolfgang Hierse, Nikolai (Mykola) Ignatyev