Abstract: Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.

Abstract: The invention relates to a fiber-reinforced plastic drilling anchor comprising an axial bore that runs along the entire length thereof, fibers which extend in the longitudinal direction thereof, and fibers that extend at an angle to the longitudinal direction thereof. A first layer of fibers that extend at an angle to the longitudinal direction of the drilling anchor is surrounded by a second layer of fibers extending in the longitudinal direction of the drilling anchor, and the second layer of fibers is surrounded by a third layer of fibers extending at an angle to the longitudinal direction of the drilling anchor. The inventive drilling anchor further comprises a thread which extends along the entire length thereof and is molded into at least one outer fiber layer of the drilling anchor. The invention also relates to a method for producing such a drilling anchor.

Abstract: The invention relates to conjugated polymers comprising bis(thienocyclopenta)benzothiadiazole units or derivatives thereof, to methods of their preparation, to novel monomer units used therein, to the use of the polymers in organic electronic (OE) devices, and to OE devices comprising the polymers.

Abstract: The invention relates to a liquid-crystalline medium based on a mixture of dielectrically negative, polar compounds which comprises at least one compound of the formula I in which the parameters have the meanings indicated in claim 1, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the VA, ECB, PALC, FFS or IPS effect, and to displays of this type.

Abstract: The present invention relates to an electro-optical light-modulation element of the FFS type, and to electro-optical displays and display systems, such as, for example, television screens and computer monitors, which contain elements of this type. The light-modulation elements according to the invention contain a liquid-crystalline modulation medium which has optimised elastic constants and are distinguished, in particular, by high contrast and/or optimised transmission in addition to good contrast, a low viewing-angle dependence, short response times and low addressing voltages. The present invention likewise relates to the liquid-crystalline modulation media used in the electro-optical light-modulation elements.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: The present invention relates to a flexible extended use regimen for a hormonal contraceptive useful to manage bleeding problems associated with fixed extended use of hormonal contraceptives and to a pharmaceutical package containing the respective hormonal contraceptive.

Abstract: The invention relates to a start-up process for a unit for producing highly thermally-integrated hydrogen by reforming a hydrocarbon feedstock that comprises a stage a wherein a burner whose purpose is to ensure start-up is supplied with a mixture of hydrocarbon feedstock and air, a stage b wherein a water stream is evaporated by indirect heat exchange with at least one of the hot streams of the process, a stage c wherein the hydrocarbon feedstock to be reformed is evaporated and heated and then introduced in gaseous form in a reforming reactor, and a stage d wherein the start-up burner is shut down, and a burner that is in permanent operation is lit.

Abstract: A gas-lift valve comprising an elongated vertically orientated tubular body with inlet ports positioned for communication with the inlet ports of a gas-lift valve mandrel, a valve seat and valve port at the upper end of the valve body, a movable gas charged dome positioned within the body below the valve seat, a valve ball assembly attached to the dome, and a collapsible bellows positioned to move the dome and manipulate the valve ball assembly downward onto and off of the valve seat in response to pressure from said inlet ports of the valve body and pressure on the seat and thereby allow injection gas to flow upward through the valve port to exit at the upper end of the valve body. A tubular latch is provided with a removable plug to provide for pressure testing and completion of the well with only one wireline trip.

Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.

Abstract: The present invention relates to 2-arylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof

Abstract: The present invention relates to processes for the production of monodisperse SiO2 particles by hydrolytic polycondensation of tetraalkoxysilanes and/or organotrialkoxysilanes, in which the hydrolytic polycondensation is carried out in a medium comprising water, one or more solubilizers and one or more amines, and in which highly monodisperse, non-porous particles are obtained. The present invention likewise relates to powders obtainable by the processes, and to the use thereof.

Abstract: Compounds of the formula I in which X, Y, R1, R1?, R2, R3 have the meanings indicated in Claim 1, are inhibitors of cell proliferation and can be employed for the treatment of tumors.

Abstract: The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

Abstract: An object of the present invention is to provide a novel semiconductor device which is excellent in stability, uniformity, reproducibility, heat resistance, durability and the like, and can exert excellent transistor properties. The semiconductor device is a thin-film transistor, and this thin-film transistor uses, as an active layer, a polycrystalline oxide semiconductor thin film containing In and two or more metals other than In and having an electron carrier concentration of less than 1×1018/cm3.

Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the ?7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: A method of automatically counting a number of inclusions by eliminating the effects of shrinkage cavities in the conventional method and securing a high correlation with a value measured by a skilled worker and a casting mold for obtaining a cast sample used for the same are provided. A method of measurement of a number of nonmetallic inclusions comprising capturing an image of a rectangular fracture surface of a cast sample consisting of an aluminum alloy by a CCD camera or other image capturing means, processing the image captured by the image capturing means for color density, digitalizing the processed image by a predetermined threshold value, and counting the number of pixel clusters of a predetermined size or more, the method characterized by detecting the end edges of the short sides of the rectangular fracture surface before the capturing of its image and automatically setting measurement regions of an area of ¼ to ? of the area of the fracture surface at the two ends of the fracture surface.

Abstract: The multiphase combination preparation for oral therapy of dysfunctional uterine bleeding and for oral contraception contains a first phase consisting of 2 daily dosage units, each containing 3 mg of estradiol valerate or <3 mg of estradiol; a second phase consisting of a first group of 5 daily dosage units, each consisting of a combination of 2 mg of dienogest with 2 mg of estradiol valerate or <2 mg of estradiol, and a second group consisting of 17 daily dosage units, each consisting of a combination of 3 mg of dienogest with 2 mg of estradiol valerate or <2 mg of estradiol; a third phase consisting of 2 daily dosage units, each containing 1 mg of estradiol valerate or <1 mg of estradiol; and another phase consisting of 2 daily dosage units of a pharmaceutically harmless placebos.

Abstract: A closure with an additive reservoir is mounted on a container for a consumable liquid. The closure has a base, which includes the additive reservoir; a spout mounted on the base; a plunger positioned in the additive reservoir, and an outer cap. Upon advancing the plunger, an additive in the reservoir is released into the consumable liquid after the additive or plunger ruptures or otherwise opens a barrier provided by a foil, membrane or plug. Upon moving the spout from a first position on the base to a second position, a passageway through the base is opened and the consumable liquid flows to the consumer without having to remove the closure. The additive chamber is mounted in a support column of the base with the passageway for the consumable liquid being disposed between the additive chamber and the support column. In a preferred embodiment the additive is the sole pressure link between the plunger and barrier.