Abstract: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.
Type:
Grant
Filed:
September 23, 2010
Date of Patent:
August 14, 2012
Assignee:
Bayer Healthcare LLC
Inventors:
Jacques Dumas, William J. Scott, James Elting, Holia Hatoum-Makdad
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds, characterized in that it comprises one or more compounds of the formula I in which R1, X1, L1-5 have the meanings indicated in Claim 1, and to the use thereof for electro-optical purposes, in particular TN monitor applications.
Type:
Grant
Filed:
December 17, 2008
Date of Patent:
August 7, 2012
Assignee:
Merck Patent Gesellschaft mit beschränkter Haftung
Inventors:
Harald Hirschmann, Michael Wittek, Sabine Schoen
Abstract: Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, Alk and D have the meanings indicated in claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
Type:
Grant
Filed:
September 9, 2008
Date of Patent:
August 7, 2012
Assignee:
Merck Patent Gesellschaft mit Beschränkter Haftung
Inventors:
Lars Thore Burgdorf, Norbert Beier, Johannes Gleitz, Ulrich Emde, Christine Charon, Denis Carniato
Abstract: Material with hierarchical porosity consisting of at least two elementary spherical particles, each one of said particles comprising a matrix based on silicon oxide, mesostructured, having a mesopore diameter ranging between 1.5 and 30 nm and exhibiting amorphous and microporous walls of thickness ranging between 1.5 and 50 nm, said elementary spherical particles having a maximum diameter of 200 microns. The matrix based on silicon oxide can contain aluminium. The preparation of said material is also described.
Type:
Grant
Filed:
August 19, 2008
Date of Patent:
August 7, 2012
Assignee:
IFP Energies nouvelles
Inventors:
Alexandra Chaumonnot, Stephanie Pega, Clement Sanchez, Cedric Boissiere
Abstract: An adjustable display frame has first and second U-shaped frame elements having aligned free end surfaces that abut to form a small display frame and are separated by first and second inert elements urged by a spring to provide a large display frame. Each U-shaped frame element has a pair of longitudinal slots which receive heads of headed studs projecting from a base disposed behind the frame elements, wherein the frame elements are secured to the base and are capable of sliding on the base from a first position, to provide the small frame, to a second position so as to provide the large frame. The inserts are slidable on the base inboard of the U-shaped frame elements and are spring biased so as to move between the free ends of the U-shaped frame elements when the U-shaped frame elements are separated by being pulled apart. Stops are provided for arresting motion of the inserts to align the inserts with the free ends of the U-shaped frame elements after the inserts have been pushed outwardly by the spring.
Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
Type:
Grant
Filed:
September 8, 2006
Date of Patent:
July 31, 2012
Assignee:
4SC AG
Inventors:
Thomas Maier, Thomas Beckers, Rolf-Peter Hummel, Martin Feth, Matthias Müller, Thomas Bär, Jürgen Volz
Abstract: This invention provides an amorphous oxide semiconductor thin film, which is insoluble in a phosphoric acid-based etching solution and is soluble in an oxalic acid-based etching solution by optimizing the amounts of indium, tin, and zinc, a method of producing the amorphous oxide semiconductor thin film, etc. An image display device (1) comprises a glass substrate (10), a liquid crystal (40) as a light control element, a bottom gate-type thin film transistor (1) for driving the liquid crystal (40), a pixel electrode (30), and an opposing electrode (50). The amorphous oxide semiconductor thin film (2) in the bottom gate-type thin film transistor (1) has a carrier density of less than 10+18 cm?3, is insoluble in a phosphoric acid-based etching liquid, and is soluble in an oxalic acid-based etching liquid.
Abstract: The present invention relates to a block copolymer derived from at least one tetrahydrofuran monomer containing 14C. The present invention also relates to a method for preparing such a block copolymer.
Type:
Grant
Filed:
October 6, 2009
Date of Patent:
July 31, 2012
Assignee:
Arkema France
Inventors:
Frederic Malet, Guillaume Le, Julien Jouanneau
Abstract: The present invention relates to novel benzimidazole-dihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, to processes for the preparation thereof and to the use thereof in therapy, especially for the treatment of diabetes.
Type:
Grant
Filed:
October 13, 2008
Date of Patent:
July 31, 2012
Assignee:
Merck Patent Gesellschaft mit beschränkter Haftung
Inventors:
Gerard Botton, Caroline Leriche, Annick Arbellot de Vacqueur, Annick Audet, Johannes Gleitz
Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising in each case one or more compounds of the formula I in which the parameters have the respective meanings indicated in the specification, and optionally one or more further dielectrically positive compounds and optionally one or more further dielectrically neutral compounds, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.
Type:
Grant
Filed:
February 25, 2009
Date of Patent:
July 31, 2012
Assignee:
Merck Patent Gesellschaft mit beschränkter Haftung
Inventors:
Markus Czanta, Michael Wittek, Lars Lietzau, Marcus Reuter, Brigitte Schuler
Abstract: A heat exchanger use high strength aluminum alloy fin material having a high strength and excellent in thermal conductivity, elusion resistance, sag resistance, sacrificial anodization effect, and self corrosion resistance, characterized by containing Si: 0.8 to 1.4 wt %, Fe: 0.15 to 0.7 wt %, Mn: 1.5 to 3.0 wt %, and Zn: 0.5 to 2.5 wt %, limiting the Mg as an impurity to 0.05 wt % or less, and having a balance of ordinary impurities and Al in chemical composition, having a metal structure before brazing of a fibrous crystal grain structure, a tensile strength before brazing of not more than 240 MPa, a tensile strength after brazing of not less than 150 MPa, and a recrystallized grain size after brazing of 500 ?m or more.
Abstract: An inorganic material that consists of at least two elementary spherical particles, each of said spherical particles comprising metal nanoparticles that are between 1 and 300 nm in size and a mesostructured matrix with an oxide base of at least one element X that is selected from the group that consists of aluminum, titanium, tungsten, zirconium, gallium, germanium, tin, antimony, lead, vanadium, iron, manganese, hafnium, niobium, tantalum, yttrium, cerium, gadolinium, europium and neodymium is described, whereby said matrix has a pore size of between 1.5 and 30 nm and has amorphous walls with a thickness of between 1 and 30 nm, said elementary spherical particles having a maximum diameter of 10 ?m. Said material can also contain zeolitic nanocrystals that are trapped within said mesostructured matrix.
Type:
Grant
Filed:
August 17, 2007
Date of Patent:
July 24, 2012
Assignee:
IFP Energies nouvelles
Inventors:
Alexandra Chaumonnot, Aurelie Coupe, Clement Sanchez, Cedric Boissiere, David Grosso
Abstract: The invention provides an exhaust gas purification catalyst comprising one or more catalyst coating layers having platinum and/or palladium with rhodium supported on a carrier, characterized in that the (platinum and/or palladium)/rhodium weight ratio is 1.0 or less.
Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising a dielectrically positive component, component A, comprising a dielectrically positive compound of the formula I in which the parameters have the meaning indicated in the specification, and optionally a second dielectrically positive component, component B, comprising one or more dielectrically positive compounds having a dielectric anisotropy of great than 3, and optionally a dielectrically neutral component, component C, and to liquid-crystal displays containing these media, especially active-matrix displays and in particular TN, IPS and FFS displays.
Type:
Grant
Filed:
April 1, 2008
Date of Patent:
July 17, 2012
Assignee:
Merck Patent Gesellschaft MIT Beschränkter Haftung
Inventors:
Markus Czanta, Andreas Taugerbeck, Renate Bender, Lars Lietzau
Abstract: A process for oligomerizing an olefinic hydrocarbon feed is described which consists of bringing said feed into contact with a catalyst comprising a silica-alumina, the silica content of said catalyst being in the range 5% to 95% by weight, said catalyst being prepared using a process comprising at least: a) mixing at least one alumina compound which is partially soluble in an acid medium with either at least one silica compound which is completely soluble in the reaction mixture or a combination formed by at least one silica compound and at least one alumina compound, said silica and alumina compounds being completely soluble in the reaction mixture, in order to form a solid precursor of said catalyst; b) hydrothermal treatment of the solid derived from step a) by calcining in moist air for a period in the range 4 to 7 hours.
Type:
Grant
Filed:
January 27, 2009
Date of Patent:
July 17, 2012
Assignee:
IFP Energies nouvelles
Inventors:
Vincent Coupard, Alexandra Chaumonnot, Laurent Simon
Abstract: The invention relates to a process of preparing regioregular polymers, in particular head-to-tail (HT) poly-(3-substituted) thiophenes or selenophenes with high regioregularity and defined molecular weight, to novel polymers prepared by this process, to the use of the novel polymers as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), electroluminescent, photovoltaic and sensor devices, and to FETs and other semiconducting components or materials comprising the novel polymers.
Type:
Grant
Filed:
December 10, 2007
Date of Patent:
July 17, 2012
Assignee:
Merck Patent GmbH
Inventors:
Timo Hoffart, Birgit Falk, Iain McCulloch, Weimin Zhang, Martin Heeney
Abstract: The invention relates to a process for the production of thermally-integrated hydrogen from a liquid hydrocarbon feedstock that contains sulfur-containing compounds that comprise at least one stage for heating the liquid hydrocarbon feedstock by indirect heat exchange with a hot stream, a stage for desulfurizing the heated hydrocarbon feedstock, a stage for evaporating the desulfurized hydrocarbon feedstock by indirect heat exchange with the hot stream that exits from the autothermal reformer, a stage for autothermal reforming of the hydrocarbon feedstock, and a stage wherein the carbon monoxide content in the hydrogen-rich gas that is produced is reduced in a reactor for converting carbon monoxide with water. The invention also relates to the hydrogen production installation that corresponds to this process.
Abstract: An aqueous coating resin composition comprising a water-dispersible nonionic resin (A) and a water-dispersible anionic core-shell resin (B), characterized in that the water-dispersible nonionic resin (A) contains a polyoxyalkylene group-containing polymerizable unsaturated monomer (a1) at 5-50 mass % of the total polymerizable unsaturated monomer used for production of the resin (A), and the water-dispersible anionic core-shell resin (B) contains an anionic group in the resin. It is possible to provide aqueous coating compositions exhibiting both satisfactory coating manageability and finished appearance.
Abstract: A crystallized solid, referred to by the name IM-14, which has an X-ray diffraction diagram as provided below, is described. Said solid has a chemical composition that is expressed according to the formula GeO2:nY2O3:pR:qF:wH2O, where R represents one or more organic radical(s), Y represents at least one trivalent element, and F is fluorine.
Type:
Grant
Filed:
October 1, 2007
Date of Patent:
July 10, 2012
Assignee:
IFP Energies Nouvelles
Inventors:
Yannick Lorgouilloux, Jean Louis Paillaud, Philippe Caullet, Joel Patarin, Nicolas Bats